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TNF-Related Activation-Induced Cytokine Enhances Leukocyte Adhesiveness: Induction of ICAM-1 and VCAM-1 via TNF Receptor-Associated Factor and Protein Kinase C-Dependent NF-κB Activation in
It is demonstrated that TNF-related activation-induced cytokine (TRANCE) has an inflammatory action and may play a role in the pathogenesis of inflammation-related diseases.
Gastrodin decreases immunoreactivities of γ‐aminobutyric acid shunt enzymes in the hippocampus of seizure‐sensitive gerbils
It is suggested that gastrodin may cause the elevation of GABA concentration by inhibiting the GABA shunt from the neuroanatomical viewpoint.
Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats
It is suggested that chronic diabetes activates microglia and significantly increases pro-inflammatory cytokine levels in the hippocampus.
Telomerase Deficiency Affects Normal Brain Functions in Mice
The results suggest that TERT is constitutively expressed in the hippocampus and the olfactory bulbs, and that it is important for regulating normal brain functions.
Ischemia‐induced changes in glucagon‐like peptide‐1 receptor and neuroprotective effect of its agonist, exendin‐4, in experimental transient cerebral ischemia
The results indicate that GLP‐1R is altered in the ischemic region after an isChemic insult and that EX‐4 protects against ischemia‐induced neuronal death possibly by increasing GLP-1R expression and attenuating microglial activation against transient cerebral ischeMIC damage.
Melatonin improves d‐galactose‐induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression
It is suggested that melatonin may be helpful in reducing age‐related phenomena in the brain by significantly ameliorating the d‐galactose‐induced increase in escape latency and neuronal damage compared with the vehicle‐treated group.
Soy isoflavones improve spatial delayed matching-to-place performance and reduce cholinergic neuron loss in elderly male rats.
Findings show that soy isoflavones can influence the brain cholinergic system and reduce age-related neuron loss and cognition decline in male rats.