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Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype
The identification of cancer stem cells (CSCs) represents an important milestone in the understanding of chemodrug resistance and cancer recurrence. More specifically, some studies have suggested… Expand
Targeting cancer stem cells by using the nanoparticles
- I. Hong, Gyu-Beom Jang, Hwa-Yong Lee, Jeong-Seok Nam
- International journal of nanomedicine
- 10 September 2015
Cancer stem cells (CSCs) have been shown to be markedly resistant to conventional cancer treatments such as chemotherapy and radiation therapy. Therefore, therapeutic strategies that selectively… Expand
MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24
- Kyung-Rok Yu, S. Lee, +5 authors Kyung-Sun Kang
- Biology, Medicine
- Journal of Cell Science
- 1 December 2013
Summary Human mesenchymal stem cell (hMSC) aging may lead to a reduced tissue regeneration capacity and a decline in physiological functions. However, the molecular mechanisms controlling hMSC aging… Expand
Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including… Expand
Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells.
Breast cancer stem cells (BCSC) are resistant to conventional chemotherapy and radiotherapy, which may destroy tumor masses but not all BCSC that can mediate relapses. In the present study, we showed… Expand
Mesenchymal stem cells and cancer: friends or enemies?
There is increasing evidence that mesenchymal stem cells (MSCs) have the ability to migrate and engraft into tumor sites and exert stimulatory effects on cancer cell growth, invasion and even… Expand
A p38 MAPK-Mediated Alteration of COX-2/PGE2 Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging
Because human mesenchymal stem cells (hMSC) have profound immunomodulatory effects, many attempts have been made to use hMSCs in preclinical and clinical trials. For hMSCs to be used in therapy, a… Expand
Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells.
- I. Hong, A. Cheung, P. C. Leung
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 August 2008
BACKGROUND The direct effects of GnRH-I or GnRH-II on apoptosis in human granulosa cells are unknown and, if present, can be influenced by FSH. Apoptosis involves activation of the intracellular… Expand
Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2.
BACKGROUND & AIMS Decreased levels or function of nucleotide-binding oligomerization domain 2 (NOD2) are associated with Crohn's disease. NOD2 regulates intestinal inflammation, and also is expressed… Expand
Double‐edged sword of mesenchymal stem cells: Cancer‐promoting versus therapeutic potential
Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and other tissues, have recently attracted much attention as potential therapeutic agents in various diseases… Expand