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Escherichia coli hemolysin may damage target cell membranes by generating transmembrane pores
It is suggested that E. coli hemolysin may damage cell membranes by partial insertion into the lipid bilayer and generation of a discrete, hydrophilic transmembrane pore with an effective diameter of approximately 3 nm, caused by the insertion of toxin monomers into the target lipid bilayers. Expand
A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria
A class of closely related ATP-binding proteins, from several bacterial species, which are associated with a variety of cellular functions including membrane transport, cell division, nodulation in Rhizobium and haemolysin export are described. Expand
Analysis of the membrane organization of an Escherichia coli protein translocator, HlyB, a member of a large family of prokaryote and eukaryote surface transport proteins.
- R. Wang, S. Séror, M. Blight, J. M. Pratt, J. Broome-Smith, I. Holland
- Biology, Medicine
- Journal of molecular biology
- 5 February 1991
It is shown in this study that both HlyB and HlyD fractionate primarily with the cytoplasmic membrane of E. coli and are accessible to proteases after removal of the outer membrane. Expand
Role of the SulB (FtsZ) protein in division inhibition during the SOS response in Escherichia coli: FtsZ stabilizes the inhibitor SulA in maxicells.
- C. Jones, I. Holland
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 September 1985
It is proposed that the SulA inhibitor interacts directly with FtsZ in vivo to block the essential division function of this protein. Expand
Structure and function of haemolysin B, P‐glycoprotein and other members of a novel family of membrane translocators
The properties of each of these remarkable proteins are described and a speculate on their possible mechanism of action is speculated. Expand
Haemolysin secretion from E coli.
The structure, function and regulation of the secretion mechanism of Haemolysin (HlyA) are discussed and it is proposed that HlyD and HlyB are essential for translocation of HlyA to the medium and these proteins form a transenvelope complex which initially binds the H-terminal targeting signal followed by transport of H-A toThe medium. Expand
Mechanism of transient inhibition of DNA synthesis in ultraviolet-irradiated E. coli: Inhibition is independent of recA whilst recovery requires RecA protein itself and an additional, inducible SOS…
It is suggested that the mechanism of recovery involves the action of Irr and RecA to promote movement of replisomes past non-instructive lesions, uncoupled from polymerisation and/or that Irrand RecA are required to promote re-initiation of a stalled replication complex downstream of a UV-lesion subsequent to such an uncoupling step. Expand
Models of Self-Organizing Bacterial Communities and Comparisons with Experimental Observations
A critical anal ysis of the validity of the model based on recent observations of the swarming bacteria which show that nutrients are not limitating but distinct subpopulations growing at different rates are lik ely present is presented. Expand
Escherichia coli haemolysin forms voltage-dependent ion channels in lipid membranes.
- G. Menestrina, N. Mackman, I. Holland, S. Bhakdi
- Chemistry, Medicine
- Biochimica et biophysica acta
- 27 November 1987
It is reported that a single toxin molecule can form a cation-selective, ion-permeable channel of large conductance in a planar phospholipid bilayer membrane, and there is quantitative agreement between the effects of this toxin on model membranes and its hemolytic properties. Expand
Secretion of haemolysin by Escherichia coli.
- N. Mackman, J. Nicaud, L. Gray, I. Holland
- Chemistry, Medicine
- Current topics in microbiology and immunology
The E. coli envelope, whose structure has been extensively reviewed, is shown and it is difficult to estimate the precise volume of the periplasmic space under normal growth conditions since it is not structurally defined. Expand