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The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of personsExpand
The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group.
This work proposes a conceptual framework and a set of guidelines that provide a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with this condition and other fatiguing illnesses. Expand
Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders
This study provides the first evidence that oxytocin nasal spray improves emotion recognition in young people diagnosed with autism spectrum disorders. Expand
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
A Systematic Review of the Impact of Adherence on the Effectiveness of e-Therapies
There is large variation in the reporting of adherence and the association of adherence with outcomes, and a lack of agreement about how best to measure adherence is likely to contribute to the variation in findings. Expand
A mega-analysis of genome-wide association studies for major depressive disorder
Although this is the largest genome-wide analysis of MDD yet conducted, its high prevalence means that the sample is still underpowered to detect genetic effects typical for complex traits, and it was unable to identify robust and replicable findings. Expand
“Stress” and coronary heart disease: psychosocial risk factors
There is strong and consistent evidence of an independent causal association between depression, social isolation and lack of quality social support and the causes and prognosis of CHD and there is no strong or consistent evidence for a causal link between chronic life events, work‐related stressors, Type A behaviour patterns, hostility, anxiety disorders or panic disorders and CHD. Expand
Clinical Staging of Psychiatric Disorders: A Heuristic Framework for Choosing Earlier, Safer and more Effective Interventions
Clinical staging with a restructure across and within diagnostic boundaries with the explicit operationalization of criteria for extent and progression of disorder should be actively explored in psychiatry as a heuristic strategy for the development and evaluation of earlier, safer, and more effective clinical interventions, and for clarifying the biological basis of psychiatric disorders. Expand
A systematic review of resting-state functional-MRI studies in major depression.
The use of resting-state fMRI in MD research has yielded a number of significant findings that provide the basis for understanding the pathophysiology of depressive symptoms and are of particular note and deserving of further research. Expand