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Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.
Allele losses from chromosome 17 are common in sporadic ovarian tumors. Previously, we reported high rates of LOH (up to 70%) from 17q25 at the marker THH59 in a bank of malignant ovarian tumors. We… Expand
Incessant ovulation and ovarian cancer
p53 mutation does not affect prognosis in ovarian epithelial malignancies
- S. Fallows, J. Price, R. Atkinson, P. Johnston, I. Hickey, S. Russell
- Biology, Medicine
- The Journal of pathology
- 1 May 2001
Mutations of the p53 tumour suppressor gene have been found in most human cancers, including ovarian epithelial malignancies. This study investigated whether the presence or absence of p53 mutation… Expand
Allelic imbalance of chromosome 6q in ovarian tumours.
Previous work has implicated putative tumour-suppressor (ts) genes at 6q27 and a broad region at 6p12-q23. Here we report the results of a coded, randomised study of allelic imbalance at 12 loci on… Expand
Early loss of heterozygosity on 17q in ovarian cancer. The Abe Ovarian Cancer Genetics Group.
We have studied 146 ovarian tumours (94 carcinomas, 22 tumours of low malignant potential and 30 benign tumours) for evidence of allele loss on chromosome 17p and 17q sufficient to imply the… Expand
Haemoglobin synthesis in inducible, uninducible and hybrid Friend cell clones.
Abstract In clone 707 of the Friend virus-induced erythroleukaemic cell line less than 1% of the cells stain detectably for haemoglobin with benzidine. On treatment with 2% dimethylsulphoxide (DMSO)… Expand
The thymidine-kinase locus of Friend erythroleukaemic cells. 1. Mutation rates and properties of mutants.
Spontaneous mutation at the thymidine-kinase locus in clone 707 of the Friend cell line has been examined. The rate of mutation in BrdU resistance was found to be 2.6 x 10(-6) cell-1 generation-1.… Expand
UV sensitivity in thymidine kinase deficient mouse erythroleukaemia cells.
Wild type Friend erythroleukaemia cells (clone 707) and thymidine kinase (EC. 22.214.171.124.1) deficient derivatives were examined for sensitivity to killing by ultra-violet (UV) irradiation. Deficiency of… Expand
Azacytidine induces reversion of thymidine kinase deficiency in Friend erythroleukemia cells.
Cells of the Friend erythroleukemia cell line show a high frequency of variants which have lost thymidine kinase activity. We have exposed a thymidine kinase-deficient clone of this cell line to a… Expand
Cytochalasin B induces abnormal chromosome segregation in Friend erythroleukaemia cells.
Friend erythroleukaemia cells were made binucleate by brief exposure to cytochalasin B (CB). The binucleate cells were then allowed to grow in the absence of the CB. They produced pseudotetraploid… Expand