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Multiple-Step Injection Molding for Fibrin-Based Tissue-Engineered Heart Valves
TLDR
A multiple-step injection molding process that enables the fabrication of TEHVs with heterogeneous composition (cell/scaffold material) of wall and leaflets without the need of gluing or suturing components together, with the leaflets firmly connected to the wall.
Biocompatibility of two model elastin‐like recombinamer‐based hydrogels formed through physical or chemical cross‐linking for various applications in tissue engineering and regenerative medicine
TLDR
Findings suggest that both types of ELRs possess broad biocompatibility, thus making them very promising for tissue engineering and regenerative medicine‐related applications.
An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair
TLDR
The results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration, whereas the ELR-based hydrogels alone led to an excellent regeneration of hyaline cartilage.
Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications.
TLDR
Hybrid gels of Elastin-Like Recombinamer (ELR) and fibrin were prepared with a range of polymer concentrations and ELR-to-fibrin ratios and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels.
Use of proteolytic sequences with different cleavage kinetics as a way to generate hydrogels with preprogrammed cell-infiltration patterns imparted over their given 3D spatial structure.
TLDR
Time-course in vivo studies proved the hypothesis that it is possible to drive the infiltration of cells over time in a given 3D-structured implant in a controlled and predesigned way that is able to overcome the natural tendency of conventional cell infiltration.
Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration
TLDR
The possibilities that elastin-based materials offer in cardiac tissue engineering, either alone or in combination with other biomaterials, are discussed to illustrate the wide range of options that are being explored.
Nanogel formation from dilute solutions of clickable elastin-like recombinamers and its dependence on temperature: two fractal gelation modes.
TLDR
Two different fractal modes of gel formation have been found at the two temperatures studied, and these different structures seem to reflect the two molecular organizations of the single components of the mixture under these conditions, namely extended chains below Tt and a spherical arrangement above Tt.
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