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- Publications
- Influence
μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis
1 Several studies have described functional interactions between opioid and cannabinoid receptors; the underlying mechanism(s) have not been well explored. One possible mechanism is direct… Expand
A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia
Opiates such as morphine are the choice analgesic in the treatment of chronic pain. However their long-term use is limited because of the development of tolerance and dependence. Due to its… Expand
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia.
- I. Gomes, A. Gupta, J. Filipovska, H. Szeto, J. Pintar, L. Devi
- Medicine
- Proceedings of the National Academy of Sciences…
- 2004
Opiates such as morphine are the choice analgesic in the treatment of chronic pain. However their long-term use is limited because of the development of tolerance and dependence. Due to its… Expand
Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.
- I. Gomes, B. Jordan, A. Gupta, N. Trapaidze, V. Nagy, L. Devi
- Biology, Medicine
- The Journal of neuroscience : the official…
- 15 November 2000
Opiate analgesics are widely used in the treatment of severe pain. Because of their importance in therapy, different strategies have been considered for making opiates more effective while curbing… Expand
Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration
The μ-δ opioid heteromer may be a target for alleviation of chronic pain. Drug-Induced Heteromers Opioid receptors are G protein–coupled receptors and are divided into μ, δ, and κ subtypes. Homomers… Expand
Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation.
- B. Jordan, N. Trapaidze, I. Gomes, R. Nivarthi, L. Devi
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 2 January 2001
G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking… Expand
D2 Receptors Regulate Dopamine Transporter Function via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent and Phosphoinositide 3 Kinase-Independent Mechanism
- E. Bolan, B. Kivell, +11 authors T. Shippenberg
- Biology, Medicine
- Molecular Pharmacology
- 1 May 2007
The dopamine transporter (DAT) terminates dopamine (DA) neurotransmission by reuptake of DA into presynaptic neurons. Regulation of DA uptake by D2 dopamine receptors (D2R) has been reported. The… Expand
Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate Synergy
- I. Gomes, B. Jordan, A. Gupta, N. Trapaidze, V. Nagy, L. Devi
- Chemistry
- The Journal of Neuroscience
- 15 November 2000
Opiate analgesics are widely used in the treatment of severe pain. Because of their importance in therapy, different strategies have been considered for making opiates more effective while curbing… Expand
Hemopressin is an inverse agonist of CB1 cannabinoid receptors
- A. Heimann, I. Gomes, +9 authors L. Devi
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 18 December 2007
To date, the endogenous ligands described for cannabinoid receptors have been derived from membrane lipids. To identify a peptide ligand for CB1 cannabinoid receptors, we used the recently described… Expand
G-protein-coupled receptor dimerization: modulation of receptor function.
G-protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors in the human genome that respond to a plethora of signals, including neurotransmitters, peptide hormones,… Expand
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