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Prestimulus effects on human startle reflex in normals and schizophrenics.
Graham (1975) demonstrated that a weak prestimulus could effectively inhibit or facilitate the eyeblink component of the startle reflex in humans, depending on the temporal duration of theExpand
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The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development.
The National Institute of Mental Health initiated the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) program to evaluate the effectiveness of antipsychotic drugs in typicalExpand
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A Meta-analysis of the Efficacy of Second-Generation Antipsychotics
Background: Consensus panel recommendations regarding choice of an antipsychotic agent for schizophrenia differ markedly, but most consider secondgeneration antipsychotics (SGAs) as a homogeneousExpand
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Randomized, controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder.
OBJECTIVE Limited randomized, controlled trial data exist on possible differences between atypical antipsychotics in efficacy, overall tolerability, and important indices of health status. TheExpand
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Olanzapine and haloperidol in first episode psychosis: Two-year data
Few studies have assessed the comparative efficacy and safety of atypical and typical antipsychotic medications in patients within their first episode of psychosis. This study examined theExpand
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Bipolar affective disorder and creativity: implications and clinical management.
Research on the relationship between creativity and mental illness is summarized, and studies documenting a relationship in writers between creativity and affective illness (particularly bipolarExpand
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Relapse and rehospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment.
BACKGROUND Previous studies have examined dose reduction and family treatment in schizophrenia, but none has examined their interaction. This study assessed the impact of dose reduction ofExpand
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Insight in first-episode psychosis.
BACKGROUND We report here a study examining the relationships between insight and psychopathology, cognitive performance, brain volume and co-morbid depression in 251 patients experiencing a firstExpand
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A meta-analysis of the efficacy of second-generation antipsychotics
BACKGROUND Consensus panel recommendations regarding choice of an antipsychotic agent for schizophrenia differ markedly, but most consider second-generation antipsychotics (SGAs) as a homogeneousExpand
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Treatment with atypical antipsychotics: new indications and new populations.
Atypical antipsychotics have revolutionized the treatment of schizophrenia, becoming the treatment of choice for patients not only during their first episode, but also throughout their life course.Expand
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