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Rapid linear scale-up of a protein separation by centrifugal partition chromatography.
The scaling up of the separation of two proteins with an aqueous two-phase system (ATPS) from 176 mg with a 500 ml laboratory scale centrifugal partition chromatography (CPC) column to 2.2g with aExpand
Counter-current chromatography for the separation of terpenoids: a comprehensive review with respect to the solvent systems employed
The collective knowledge on performing successful CCC separations of terpenoids has been gathered and reviewed by the authors, in order to create a comprehensive document that will be of great assistance in performing future purifications. Expand
Improved hydrophilic interaction chromatography method for the identification and quantification of glucosinolates.
An improved hydrophilic interaction liquid chromatography (HILIC) method has been developed to separate members of a closely related family of chemoprotective phytochemicals called glucosinolates, using a silica-based permanently zwitterionic stationary phase. Expand
Scalable technology for the extraction of pharmaceutics: outcomes from a 3 year collaborative industry/academia research programme.
This paper reports on some of the key outcomes of a 3 year £1.5m Technology Strategy Board (TSB) funded research programme to develop a small footprint, versatile, counter-current chromatographyExpand
Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography.
This is the first time that high-performance counter-current chromatography has been used to purify multiple gram grade bioactive compounds in less than 1h and at such high concentrations of final products (10.8 g/l for magnolol and 7.0 g/ l for honokiol). Expand
Simple Approach to the Development of a CCC Solvent Selection Protocol Suitable for Automation
Abstract One of the biggest problems with countercurrent chromatography, when it comes to its practical application in an industrial environment, is developing a protocol and corresponding solventExpand
Counter-current chromatography separation scaled up from an analytical column to a production column.
An analytical separation was performed on an analytical J-type counter-current chromatography (CCC) instrument using a 5.4 ml column, with a 1 ml/min mobile phase flow rate, and the underlying scale up theory was presented. Expand
A comprehensive classification of solvent systems used for natural product purifications in countercurrent and centrifugal partition chromatography.
Using both library paper copies and modern electronic copies, every known, published, English-language journal paper that employs either countercurrent or centrifugal partition chromatography solventExpand
Minimising Solvent Usage in High Speed, High Loading, and High Resolution Isocratic Dynamic Extraction
Abstract The development of the planetary‐motion countercurrent chromatography machine into a high speed, high loading and high resolution dynamic extraction centrifuge has allowed the scale‐up ofExpand