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Cardiotoxicity of anthracyclines.
This study describes the effects of some anthracyclines (adriamycin, 4-epiadriamycin and esorubicin) on isolated, electrically driven left guinea pig atrium in normodynamic or hypodynamic (TyrodeExpand
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Potential antitumor agents XIX [1]. Synthesis and antitumor activity of tricyclic compounds related to lotifazole.
The synthesis of phenothiazine and anthraquinone derivatives, bearing at least one fragment present in lotifazole, is reported. Some of the new compounds showed antitumor activity in vitro (P388Expand
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Effect of various antitumor drugs on energetic processes.
Abstract Activity of some anti-tumor drugs on respiration and anaerobic glycolysis of Ehrlich's ascites cells and of rat brain homogenates, as well as on respiration of rat liver homogenates asExpand
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Influence of calcium and calcium-modulating agents on differentiation of murine erythroleukaemia cells.
Since the involvement of calcium ions in the regulation of cell division and differentiation has been proposed, in this study we have examined the effect of extracellular calcium and ofExpand
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Antinociceptive effect of centrally administered cimetidine and dimaprit in the rat.
Cimetidine, an H2 receptor antagonist, administered into a lateral ventricle of the rat brain caused a significant increase in tail flick latency. Dimaprit, a specific H2 agonist, failed toExpand
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Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams
The synthesis of pyridylmethylene lactams and indolylmethylene-2-indolinones is reported. These compounds were tested for their cytotoxic and positive inotropic activity. The presence of both theExpand
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Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones
Summary A compound endowed with coanthracyclinic activity should potentiate the antitumor activity of anthracyclines while counteracting their cardiodepressant effect. We now report the synthesis andExpand
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Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures ofExpand
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Interaction between Doxorubicin and Mitomycin C on Mortality and Myocardial Contractility in Guinea PIG
The present investigations were carried out in guinea pig to ascertain whether mitomycin C has a direct cardiotoxic effect or interacts with doxorubicin-induced cardiotoxicity. I.p. administration ofExpand
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