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Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the
Inhaled ultrafine particles show considerably stronger pulmonary inflammatory effects when tested at equal mass dose with their fine counterparts. However, the responsible mechanisms are not yetExpand
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Low doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic development.
Several in vitro and in vivo studies suggest local and systemic effects following exposure to carbon nanotubes. No data are available, however, on their possible embryotoxicity in mammals. In thisExpand
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Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects.
Experimental studies indicate that carbon nanotubes (CNTs) have the potential to induce adverse pulmonary effects, including alveolitis, fibrosis, and genotoxicity in epithelial cells. Here, weExpand
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Physico-chemical features of engineered nanoparticles relevant to their toxicity
Abstract Nanotoxicology studies require investigations of several physico-chemical aspects of the particle/body fluid interaction, here described by reviewing recent literature in the light of newExpand
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Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay
BackgroundCarbon nanotubes (CNT) can induce lung inflammation and fibrosis in rodents. Several studies have identified the capacity of CNT to stimulate the proliferation of fibroblasts. We developedExpand
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Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: physicochemical aspects.
Carbon nanotubes (CNT) have been reported to elicit toxic responses in vitro and in vivo, ascribed so far to metal contamination, CNT length, degree of oxidation, or extent of hydrophilicity. ToExpand
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Reactivity of carbon nanotubes: free radical generation or scavenging activity?
Carbon nanotubes (CNTs) currently attract intense research efforts because of their unique properties which make them suitable for many industrial applications. When inhaled, CNTs constitute aExpand
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Thickness of multiwalled carbon nanotubes affects their lung toxicity.
Two samples of highly pure multiwalled carbon nanotubes (MWCNTs) similar in hydrophobicity and surface reactivity were prepared with similar length, <5 μm, but markedly different diameter (9.4 vs 70Expand
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Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity.
Indium-Tin-Oxide (ITO) is a sintered mixture of indium- (In(2)O(3)) and tin-oxide (SnO(2)) in a ratio of 90:10 (wt:wt) that is used for the manufacture of LCD screens and related high technologyExpand
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Possible role of ascorbic acid in the oxidative damage induced by inhaled crystalline silica particles.
The selective interaction of ascorbic acid with crystalline silica (quartz) has been studied by measuring the ascorbic acid consumption (by means of UV/vis and IR spectroscopy) and the release ofExpand
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