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Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
TLDR
It transpires that although rMs are dispensable for clearing PMNs during self-limiting inflammation, they are essential for signaling postresolution lymphocyte repopulation via COX 2 lipids, with a role in mediating postresolution innate-lymphocyteRepopulation and restoring tissue homeostasis.
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
TLDR
It is concluded that DJ-1 is not an essential component of LBs and Lewy neurites, is expressed mainly by astrocytes in human brain tissue and is sensitive to oxidative stress conditions, consistent with the hypothesis that neuronal-glial interactions are important in the pathophysiology of Parkinson's disease.
Epicardial Adipokines in Obesity and Coronary Artery Disease Induce Atherogenic Changes in Monocytes and Endothelial Cells
TLDR
EAT products are altered in both obesity and CAD and induce atherogenic changes in relevant target cells, which are exacerbated in those with CAD.
Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
TLDR
A role for NRP1 and N RP1 glycosylation in mediating PDGF-induced VSMC migration is indicated, possibly by acting as a co-receptor for PDGFRα and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway.
Neuropilin-1 Signaling through p130Cas Tyrosine Phosphorylation Is Essential for Growth Factor-Dependent Migration of Glioma and Endothelial Cells
TLDR
It is reported that p130Cas tyrosine phosphorylation is stimulated by hepatocyte growth factor and platelet-derived growth factor in U87MG glioma cells and VEGF in endothelial cells and is dependent on NRP1 via its intracellular domain and identified a critical role for a novel N RP1-p130Cas pathway in the regulation of chemotaxis.
Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury
TLDR
NRP1 and NRP2 play important roles in the regulation of neointimal hyperplasia in vivo by modulating VSMC migration and proliferation and proliferation, independently of the role of NRPs in re-endothelialization.
The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis
TLDR
Findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease.
The role of neuropilins in cell signalling.
TLDR
Growing evidence indicates that NRP1 plays a selective role in signalling at least in part via its C-terminal domain and interaction with intracellular binding partners.
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