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Endocytic and Transcytotic Processes in Villous Syncytiotrophoblast: Role in Nutrient Transport to the Human Fetus
TLDR
The placenta is a tissue where intensive cell biological research is required to unravel endocytic trafficking pathways in a highly specialized cell such as the STB, and the potential mechanisms of transplacental IgG, iron, lipoprotein and glucose transport are presented. Expand
Skin Lesion Classification Using Hybrid Deep Neural Networks
TLDR
This work proposes a fully automatic computerised method for skin lesion classification which employs optimised deep features from a number of well-established CNNs and from different abstraction levels. Expand
Immunology of Osteoporosis: A Mini-Review
TLDR
Osteoporosis is a major cause of fractures and associated morbidity in the aged population and oxidative stress and the generation of advanced glycation end products have emerged as links between inflammation and bone destruction. Expand
Intracellular traffic of the MHC class I-like IgG Fc receptor, FcRn, expressed in epithelial MDCK cells.
TLDR
Findings provide direct evidence for the transepithelial transport function of FcRn and indicate that the receptor undergoes multiple rounds of transcytosis. Expand
The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer
TLDR
Investigation of the expression of poorly characterized OATPs, namely OATP2A1, O ATP3A 1, OatP4A1 and OATp5A1 in hepatic cancer of different origin suggests that these transporters might be further exploited for the discovery of novel anticancer agents. Expand
Fusing fine-tuned deep features for skin lesion classification
TLDR
The obtained results convincingly demonstrate the proposed approach to represent a reliable and robust method for feature extraction, model fusion and classification of dermoscopic skin lesion images. Expand
A Multi-Organ Nucleus Segmentation Challenge
TLDR
Several of the top techniques compared favorably to an individual human annotator and can be used with confidence for nuclear morphometrics as well as heavy data augmentation in the MoNuSeg 2018 challenge. Expand
IgG transport across trophoblast‐derived BeWo cells: a model system to study IgG transport in the placenta
TLDR
Results suggest a mechanism by which IgG is internalized by BeWo cells via fluid‐phase endocytosis, which would prevent entry of IgG into the degradative pathway in lysosomes. Expand
Physiology and Pathophysiology of Steroid Biosynthesis, Transport and Metabolism in the Human Placenta
TLDR
While steroid production, metabolism and transport in the placental syncytiotrophoblast have been explored for decades, few information is available for the role of placental-fetal endothelial cells in these processes. Expand
Placental Alkaline Phosphatase Expression at the Apical and Basal Plasma Membrane in Term Villous Trophoblasts
TLDR
After in vitro differentiation into syncytia, PLAP plasma membrane expression was upregulated and exceeded that observed in mononuclear trophoblasts, calling for caution in using PLAP as a morphological marker to differentiatesyncytiotrophoblast from cytotrophoblasts or as a marker enzyme for placental brush-border membranes. Expand
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