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PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal.
- T. Liechtenstein, I. Dufait, +4 authors D. Escors
- Journal of clinical & cellular immunology
- 30 October 2012
The potential mechanisms and the therapeutic consequences by which interference/inhibition with PD-1/PD-L1 negative co-stimulation during antigen presentation to T cells results in anti-tumour immunity are discussed. Expand
Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer
The role of MDSC as inhibitors of T-cell-mediated immune responses in CRC, which differentiated in vitro from bone marrow cells using conditioned medium of GM-CSF-secreting CT26 cells, represent a valuable platform to study/identify drugs that counteract M DSC activities. Expand
Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy
- I. Dufait, E. Van Valckenborgh, E. Menu, D. Escors, M. de Ridder, K. Breckpot
- 23 March 2016
A review will focus on the role of this key transcription factor during the MDSC's life cycle and on the therapeutic opportunities it offers. Expand
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy
Evaluation of vaccines in healthy mice has no significant predictive value for the selection of anticancer treatments, and B16 cells expressing xenoantigens as a tumor model are of limited value; vaccines which inhibit the suppressive effect of MDSC on T cells in the authors' ex vivo assay show promising and relevant antitumor activities. Expand
Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption
The results demonstrate that metformin and phenformin overcome hypoxic radioresistance through inhibition of mitochondrial respiration, and provide a rationale to explore met formin and Phenformin as hypoxic radiosensitizers. Expand
Assessing T-cell responses in anticancer immunotherapy
It is proposed that the immunomodulatory activity of MDSCs should be carefully considered for the development of efficient anticancer immunotherapies. Expand
Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
The findings illuminate TrxR in cancer cells as an exploitable radiobiological target and warrant further validation of AF in combination with radiotherapy. Expand
MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.
- T. Liechtenstein, I. Dufait, A. Lanna, K. Breckpot, D. Escors
- Immunology, endocrine & metabolic agents in…
- 31 August 2012
This review will address the experimental strategies to interfere with negative co-stimulation such as that mediated by PD-L1 (programmed cell death 1 ligand 1)/PD-1 (Programmed death 1) to enhance anti-tumour immunity. Expand
Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance
Three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from d endritic cells using microRNA technology. Expand
Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion.
- W. Leonard, I. Dufait, +9 authors M. de Ridder
- Radiotherapy and oncology : journal of the…
- 1 May 2016
Protumor Arg(+) MDSC reveal a unique ability to radioprotect tumor cells through l-arginine depletion, a common mechanism behind both T-cell and macrophage inhibition. Expand