I. Dransfield

Publications185
h-index50
Citations12,006
Highly Influential Citations421
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A blast from the past: clearance of apoptotic cells regulates immune responses
Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of… Expand
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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of inflammation. Here we report that human neutrophils contain functionally active… Expand
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Divalent cation regulation of the function of the leukocyte integrin LFA-1
The integrin lymphocyte function-associated antigen-1 (LFA-1) expressed on T cells serves as a useful model for analysis of leukocyte integrin functional activity. We have assessed the role of… Expand
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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
Resistance to chemotherapy is a principal problem in the treatment of small cell lung cancer (SCLC). We show here that SCLC is surrounded by an extensive stroma of extracellular matrix (ECM) at both… Expand
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Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
PHAGOCYTE recognition of cells that have undergone apoptosis (programmed cell death) is an event of broad biological significance. Characterized by endogenous endonuclease activation1, which results… Expand
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Diversification of TAM receptor function
The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct roles as… Expand
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Functional and clinical consequences of Fc receptor polymorphic and copy number variants
Receptors for immunoglobulins (Fc receptors) play a central role during an immune response, as they mediate the specific recognition of antigens of almost infinite diversity by leucocytes, thereby… Expand
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Increased Platelet Binding to Circulating Monocytes in Acute Coronary Syndromes
Background—Present therapies for acute coronary syndromes aim toward limiting platelet–platelet adhesion and aggregation processes. However, platelet–leukocyte interactions may contribute importantly… Expand
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Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro.
Granulocyte apoptosis is an important mechanism underlying the removal of redundant neutrophils from an inflammatory focus. The ability of many proinflammatory agents to impede this event suggests… Expand
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Priming differentially regulates neutrophil adhesion molecule expression/function
Lung injury in a variety of disease states is critically dependent on neutrophil‐mediated inflammatory responses. Neutrophil recruitment to sites of infection or tissue damage requires co‐ordinated… Expand
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