• Publications
  • Influence
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of
Objective:To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients. Participants:A multidisciplinary, multispecialty taskExpand
Angiopoietin‐2 is increased in severe sepsis: Correlation with inflammatory mediators
First, patients’ serum Ang‐2 levels are increased during severe sepsis and associated with disease severity, and the strong relationship of serum angiopoietin with serum tumor necrosis factor‐&agr; suggests that the latter may participate in the regulation of Ang‐ 2 production in sepsi. Expand
High Incidence of Neuroendocrine Dysfunction in Long-Term Survivors of Aneurysmal Subarachnoid Hemorrhage
Long-term survivors of aneurysmal SAH frequently exhibit endocrine changes, with growth hormone and gonadal deficiencies predominating, and screening of pituitary function is recommended in patients surviving SAH. Expand
Detection of expiratory flow limitation during exercise in COPD patients.
In conclusion, NEP provides a rapid and reliable method to detect expiratory flow limitation at rest and during exercise. Expand
Impact of catheter-related bloodstream infections on the mortality of critically ill patients: A meta-analysis*
Presence, as opposed to absence, of CR-BSI is associated with higher mortality in critically ill adult patients, and this finding seems to justify and may enhance efforts to prevent CR- BSI in such patients. Expand
Phrenic nerve dysfunction after cardiac operations: electrophysiologic evaluation of risk factors.
Among the risk factors investigated, only the use of ice slush was significantly associated with postoperative phrenic nerve dysfunction, and ice should be avoided in cardiac surgery, since it does not seem to provide additional myocardial protection. Expand
Health-Related Quality of Life and Disability in Survivors of Multiple Trauma One Year After Intensive Care Unit Discharge
The majority of survivors of major trauma exhibit considerable levels of disability and impairment in health-related quality of life, and this information may help in organizing long-term rehabilitation of multiple-trauma patients. Expand
Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: Incidence, pathophysiology, and relationship to vasopressor dependence and peripheral
Adrenal cortisol secretion after dynamic stimulation is deficient in a subset of critically ill patients with moderate to severe head injury and this disorder is associated with prior vasopressor dependency and higher interleukin-6 levels. Expand
Pulmonary toxicity from novel antineoplastic agents.
Clinicians should be aware of the potential of most novel antineoplastic agents to cause lung toxicity, and a high index of suspicion is required if these are combined with other cytotoxic drugs or radiation. Expand
Effects of severity of long-standing congestive heart failure on pulmonary function.
The data suggest that respiratory abnormalities, such as restrictive defects, airway obstruction, and inspiratory muscle weakness, are more pronounced in patients with severe CHF than in those with mild-to-moderate disease. Expand