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Guidelines for the use and interpretation of assays for monitoring autophagy
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
It is proposed that phosphorylation of autophagy receptors might be a general mechanism for regulation of cargo-selectiveautophagy, resulting in increased intracellular bacterial proliferation. Expand
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
It is proposed that Pyk2 acts with Src to link Gi- and Gq-coupled receptors with Grb2 and Sos to activate the MAP kinase signalling pathway in PC12 cells. Expand
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
NBR1 (neighbor of BRCA1 gene 1) is an autophagy receptor containing LC3- and ubiquitin (Ub)-binding domains and it is proposed that NBR1 and p62 act as receptors for selective autophagosomal degradation of ubiquitinated targets. Expand
Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis
The identification of two ubiquitin (Ub)–binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols), indicate that Ub-binding domains of Y- family polymerases play crucial regulatory roles in TLS. Expand
A role for ubiquitin in selective autophagy.
The hypothesis that ubiquitin represents a selective degradation signal suitable for targeting various types of cargo, ranging from protein aggregates to membrane-bound organelles and microbes, is explored. Expand
Nix is a selective autophagy receptor for mitochondrial clearance
Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation, and ablation of the Nix:LC3/GABARAP interaction retards mitochondrial clearance in maturing murine reticulocytes. Expand
Specification of SUMO1- and SUMO2-interacting Motifs*
SUMO proteins are ubiquitin-related modifiers implicated in the regulation of gene transcription, cell cycle, DNA repair, and protein localization. The molecular mechanisms by which the sumoylationExpand
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
It is concluded that haploinsufficiency of TBK1 causes ALS and fronto-temporal dementia. Expand
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
It is shown that the epidermal growth factor and platelet-derived growth factor receptors are not polyubiquitinated but rather are monoubiquitination at multiple sites after their ligand-induced activation and a single ubiquitin is sufficient for both receptor internalization and degradation. Expand