Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
Genome-wide association study identifies 74 loci associated with educational attainment
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
The neuroscience of human intelligence differences
Genetics and brain imaging studies have identified differences in brain pathways, especially parieto-frontal pathways, that contribute to intelligence differences, and there is also evidence that brain efficiency correlates positively with intelligence.
Complement C3 variant and the risk of age-related macular degeneration.
The common functional polymorphism rs2230199 in the C3 gene, corresponding to the electrophoretic variants C3S and C3F, was strongly associated with age-related macular degeneration in both the English group and the Scottish group and underscores the influence of the complement pathway in the pathogenesis of this disease.
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
A genetic meta-analysis of depression found 269 associated genes that highlight several potential drug repositioning opportunities, and relationships with depression were found for neuroticism and smoking.
What Intelligence Tests Miss: The Psychology of Rational Thought
Intelligence and educational achievement
Age-associated cognitive decline.
Age-associated cognitive decline-or normal (non-pathological, normative, usual) cognitive ageing-is an important human experience which differs in extent between individuals, and factors affecting general bodily ageing also influence cognitive functions in old age.