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Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
In mammalian cells and Xenopus embryos, Wnt/Fz signaling coactivates Rho and Rac, another GTPase and distinct regulator of cytoskeletal architecture, which is required for cell polarity and movements during vertebrate gastrulation. Expand
A new secreted protein that binds to Wnt proteins and inhibits their activites
Wnt-inhibitory factor-1 (WIF-1) is described, a secreted protein that binds to Wnt proteins and inhibits their activities, and results indicate that WNT proteins interact with structurally diverse extracellular inhibitors to fine-tune the spatial and temporal patterns of Wnt activity. Expand
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
Results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of G SK-3 activity by a wingless/wnt-related signal. Expand
Repeated genes in eukaryotes.
A large number of the ribosomal genes affected by the bobbed locus mutation in Drosophila belong to the TSP class, which has been associated with central giant cell reprograming. Expand
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.
The structure, inducibility, and localized expression in the organizer of the Xlim-1 gene suggest that it has a role in establishing body pattern during gastrulation. Expand
Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry.
It is suggested that Ndr1 has a role in mesoderm induction, while Ndr2 is involved in subsequent specification and patterning of the nervous system and establishment of laterality. Expand
Identification of Sef, a novel modulator of FGF signalling
The identification of a novel modulator of FGF signal transduction, sef, isolated from a zebrafish embryo library through an in situ hybridization screen is reported, suggesting that Sef is required to limit FGF signalling during development. Expand
Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm.
Early neural patterning in vertebrates involves signals that inhibit anterior (A) and promote posterior (P) positional values within the nascent neural plate. In this study, we have investigated theExpand
Zebrafish foxi1 mediates otic placode formation and jaw development
It is shown that hearsay disrupts foxi1, a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; foxi 1 appears to be the earliest marker known for the otic anlage. Expand
cyclops encodes a nodal-related factor involved in midline signaling.
It is reported that the cyclops locus encodes the nodal-related protein Ndr2, a member of the transforming growth factor type beta superfamily of factors, which is required for ventral midline patterning of the embryonic central nervous system. Expand