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Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice.
TLDR
Data suggest that POP Tb might contribute to the pathogenesis of sleeping sickness, as it hydrolyzes peptide hormones containing Pro or Ala at the P1 position at a slightly alkaline pH and cleaves type I collagen in vitro and native collagen present in rat mesentery. Expand
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.
TLDR
The cloning of the POPTc80 gene is presented, whose deduced amino acid sequence shares considerable identity with other members of the Pop family, mainly within its C-terminal portion that forms the catalytic domain. Expand
Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition
TLDR
The EO from F. galbaniflua showed to be effective against L. amazonensis promastigotes forms and presented low cytotoxic activity against L6 cells, which represents a strong candidate for future studies aiming its molecular activity on these pathogenic parasites. Expand
The Repetitive Cytoskeletal Protein H49 of Trypanosoma cruzi Is a Calpain-Like Protein Located at the Flagellum Attachment Zone
TLDR
H49/calpains could have a structural role, namely that of ensuring that the cell body remains attached to the flagellum by connecting the subpellicular microtubule array to it in trypanosomatid lineages. Expand
Emerging Chagas Disease
Dendritic Cells: A Double-Edged Sword in Immune Responses during Chagas Disease
TLDR
The parasite ability to manipulate DCs activity for the purpose of evading innate immune response and assuring its own survival and persistence is pointed out. Expand
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
TLDR
It is demonstrated that sera from both chagasic rabbits and humans have specific antibodies to highly purified native oligopeptidase B and cathepsin B, which may be associated with Chagas' disease pathogenesis by hydrolyzing host proteins and inducing host immune responses. Expand
A Deep Insight into the Sialome of Rhodnius neglectus, a Vector of Chagas Disease
TLDR
The data presented improve the understanding of hematophagous arthropod sialomes, and aid in understanding hematophileagy and the complex interplay among vectors and their vertebrate hosts. Expand
Cell surface proteome analysis of human-hosted Trypanosoma cruzi life stages.
TLDR
Bioinformatic analysis showed that the vast majority of the identified proteins are membrane-derived and/or possess predicted transmembrane domains, mainly involved in host cell infection, protein adhesion, cell signaling, and the modulation of mammalian host immune response. Expand
Larvicidal and pupicidal activities of eco-friendly phenolic lipid products from Anacardium occidentale nutshell against arbovirus vectors
TLDR
This study suggests that Anacardium occidentale nut shell derivatives are sustainable and promising candidates for the development of novel insecticides to overcome the problem of harmful chemical insecticides. Expand
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