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Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function
16 new regions showing association with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM, SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2 are identified.
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Ten new risk loci are identified for atopic dermatitis, bringing the total number of known atopic skin disease susceptibility loci to 31 (with new secondary signals at four of these loci), underscoring the important contribution of (auto)immune mechanisms to atopy dermatitis pathogenesis.
Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults.
- A. Mehta, D. Miedinger, N. Künzli
- MedicineAmerican journal of respiratory and critical care…
- 14 December 2012
In a Swiss working adult population, occupational exposure-associated risk of stage II+ COPD was observed mainly in males and ages ≥ 40 years, and remained elevated when restricted to nonsmokers.
META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES IDENTIFIES THREE NEW RISK LOCI FOR ATOPIC DERMATITIS
A genome-wide association meta-analysis of affected individuals and controls and the ten most strongly associated new susceptibility loci examined underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
- J. Wilk, N. Shrine, B. Stricker
- Biology, MedicineAmerican journal of respiratory and critical care…
- 1 October 2012
An important role is suggested for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.
Prevalence of airflow obstruction in smokers and never-smokers in Switzerland
- P. Bridevaux, N. Probst-Hensch, E. Russi
- Medicine, EngineeringEuropean Respiratory Journal
- 22 April 2010
Never-smokers were younger, more likely to be male and reported asthma more frequently than obstructive smokers, and age, smoking, and asthma were associated with airflow obstruction.
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
The findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
Genetic heterogeneity of asthma phenotypes identified by a clustering approach
Latent class analysis (LCA) was applied in 3001 adults ever having asthma recruited in the frame of three epidemiological surveys, providing evidence that a better understanding of asthma phenotypic heterogeneity helps to disentangle the genetic heterogeneity of asthma.
Serum bilirubin is associated with lung function in a Swiss general population sample
- I. Curjuric, M. Imboden, N. Probst-Hensch
- Medicine, BiologyEuropean Respiratory Journal
- 31 October 2013
The results suggest a possible protective role of bilirubin on lung tissue, which could be important for prevention and therapy.