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Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
TMPRSS2:ERG gene fusions and PTEN deletions are the most common genomic aberrations in prostate cancer. Recent work has suggested that the TMPRSS2:ERG fusion is associated with a more aggressive… Expand
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
- M. Yoshimoto, I. Cunha, +4 authors J. Squire
- Biology, Medicine
- British Journal of Cancer
- 14 August 2007
This study examines the clinical impact of PTEN genomic deletions using fluorescence in situ hybridisation (FISH) analysis of 107 prostate cancers, with follow-up information covering a period of up… Expand
Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases.
PURPOSE We evaluated clinicopathological features and outcomes in patients with penile squamous cell carcinoma. MATERIALS AND METHODS We studied 333 patients with homogeneous surgical treatment,… Expand
GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker
OBJECTIVE: To analyze glucose transporter 1 expression patterns in malignant tumors of various cell types and evaluate their diagnostic value by immunohistochemistry. INTRODUCTION: Glucose is the… Expand
Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy
Current non-invasive approaches for detection of urothelial cancers are suboptimal. We developed a test to detect urothelial neoplasms using DNA recovered from cells shed into urine. UroSEEK… Expand
GATA3 expression in primary vulvar Paget disease: a potential pitfall leading to misdiagnosis of pagetoid urothelial intraepithelial neoplasia
GATA3 has been reported as a specific urothelial marker among organs in the pelvic region, and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was… Expand
Pseudoglandular (Adenoid, Acantholytic) Penile Squamous Cell Carcinoma: A Clinicopathologic and Outcome Study of 7 Patients
- I. Cunha, G. Guimarães, +5 authors A. Cubilla
- The American journal of surgical pathology
- 1 April 2009
Almost half of penile squamous cell carcinomas (SCCs) are of the usual type but there is a variegated spectrum of morphologically distinctive subtypes. In a pathologic review of 375 uniformly… Expand
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Overexpression of fatty acid synthase (FASN) and ErbB2 has been described in oral squamous cell carcinomas (OSCC). FASN is the key lipogenic enzyme responsible for the endogenous synthesis of fatty… Expand
Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors.
Soft tissue tumors represent a group of neoplasia with different histologic and biological presentations varying from benign, locally confined to very aggressive and metastatic tumors. The molecular… Expand
Immunohistochemical assessment of PTEN in vulvar cancer: best practices for tissue staining, evaluation, and clinical association.
- A. M. Lavorato-Rocha, L. G. Anjos, I. Cunha, J. Vassallo, F. Soares, R. Rocha
- Medicine, Biology
- 1 May 2015
BACKGROUND Pten encodes a well-characterized protein that is important in several cancers due to its tumor suppressor function. Yet, the detection and evaluation of PTEN by immunohistochemistry (IHC)… Expand