Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity
C1-1 is a novel model compound for inhibiting HBV replication by blocking capsid formation and provides a new basis for the development of therapeutic molecules with specific antiviral potential against HBV infections.
The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells
It is indicated that the EZH2 gene plays a role for both the proliferation and the apoptosis resistance of RCC cells, and could represent a novel strategy to improve the therapeutic response of R CC.
Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene
Evidence is provided that the intracellular interference with Livin gene expression resensitizes human tumor cells to apoptosis and it is shown that the livin gene is susceptible to efficient and specific silencing by the siRNA technology.
Peptide aptamers: specific inhibitors of protein function.
- F. Hoppe-Seyler, I. Crnković-Mertens, E. Tomai, K. Butz
- Biology, ChemistryCurrent molecular medicine
- 31 July 2004
Peptide aptamers can be used in order to validate therapeutic targets at the intracellular level and should possess therapeutic potential, both as lead structures for drug design and as a basis for the development of protein drugs.
The Immunoevasive Function Encoded by the Mouse Cytomegalovirus Gene m152 Protects the Virus against T Cell Control in Vivo
- A. Krmpotić, M. Messerle, I. Crnković-Mertens, B. Polić, S. Jonjić, U. Koszinowski
- BiologyJournal of Experimental Medicine
- 1 November 1999
Results prove that MHC-reactive functions protect CMVs against attack by CD8+ T lymphocytes in vivo, and delete of the m152 gene has no effect on virus replication in cell culture, whereas after infection of mice, the m 152-deficient virus replicates to significantly lower virus titers.
Isoform-specific silencing of the Livin gene by RNA interference defines Livin β as key mediator of apoptosis inhibition in HeLa cells
- I. Crnković-Mertens, J. Semzow, F. Hoppe-Seyler, K. Butz
- BiologyJournal of molecular medicine
- 1 March 2006
It is concluded that the Livin β isoform plays the key role for the antiapoptotic protection of HeLa cells by the livin gene.
Virus Attenuation after Deletion of the Cytomegalovirus Fc Receptor Gene Is Not due to Antibody Control
It is demonstrated that the cell surface-expressed viral glycoprotein with FcR activity strongly modulates the virus-host interaction but that this biological function is not caused by the immunoglobulin binding property.
The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells.
Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney
- N. Wagener, I. Crnković-Mertens, F. Hoppe-Seyler
- Biology, MedicineBritish Journal of Cancer
- 30 October 2007
The relative overexpression of livin in renal cell carcinoma indicates that it may still represent a therapeutic target to increase the apoptotic sensitivity of kidney cancer cells, but this strategy is likely to be not tumour-specific.
Isolation of peptides blocking the function of anti-apoptotic Livin protein
- I. Crnković-Mertens, J. Bulkescher, Christina Mensger, F. Hoppe-Seyler, K. Hoppe‐Seyler
- Biology, ChemistryCellular and Molecular Life Sciences
- 23 February 2010
Evidence is provided that the targeted inhibition of Livin by peptides represents a viable approach for the apoptotic sensitization and growth inhibition of tumor cells.