I. Crawford

Publications111
h-index35
Citations4,397
Highly Influential Citations100
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Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications.
Two anthranilate synthase gene pairs have been identified in Pseudomonas aeruginosa. They were cloned, sequenced, inactivated in vitro by insertion of an antibiotic resistance gene, and returned to… Expand
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The complete nucleotide sequence of the tryptophan operon of Escherichia coli.
The tryptophan (trp) operon of Escherichia coli has become the basic reference structure for studies on tryptophan metabolism. Within the past five years the application of recombinant DNA and… Expand
  • 251
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Evolution of a biosynthetic pathway: the tryptophan paradigm.
  • I. Crawford
  • Biology, Medicine
  • Annual review of microbiology
  • 1989
Article de synthese sur la voie de biosynthese du tryptophane chez les bacteries. Anthranilate synthase. Phosphoribosyltransferase. Indoleglyceral phosphate synthase-N-Phosphoribosylanthranilate… Expand
  • 177
  • 5
An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase…
McDonald and Burke (J. Bacteriol. 149:391-394, 1982) previously cloned a sulfanilamide-resistance gene, sul, residing on a 4.9-kb segment of Bacillus subtilis chromosomal DNA, into plasmid pUB110. In… Expand
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Evolutionary differences in chromosomal locations of four early genes of the tryptophan pathway in fluorescent pseudomonads: DNA sequences and characterization of Pseudomonas putida trpE and trpGDC.
Pseudomonas putida possesses seven structural genes for enzymes of the tryptophan pathway. All but one, trpG, which encodes the small (beta) subunit of anthranilate synthase, have been mapped on the… Expand
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Central nervous system syndromes of "vital" etiology. A study of 713 cases.
Abstract Careful etiologic study of 713 patients with disease of the central nervous system of presumed "viral" etiology related forty immunologically distinct infectious agents to the diseases.… Expand
  • 265
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Transformation studies on the linkage of markers in the tryptophan pathway in Bacillus subtilis.
  • 84
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DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa.
Two pairs of related but easily distinguishable genes for the two subunits of anthranilate synthase have been identified in Pseudomonas aeruginosa. These were cloned, sequenced, inactivated in vitro… Expand
  • 62
  • 3
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In vitro determination of the effect of indoleglycerol phosphate on the interaction of purified TrpI protein with its DNA-binding sites.
Expression of the trpBA gene pair of Pseudomonas aeruginosa is regulated by the endogenous level of indoleglycerol phosphate (InGP) and the trpI gene product. The TrpI protein binds to the -77 to -32… Expand
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The Rhizobium meliloti trpE(G) gene is regulated by attenuation, and its product, anthranilate synthase, is regulated by feedback inhibition.
In Rhizobium meliloti, the genes involved in biosynthesis of the amino acid tryptophan are found at three separate chromosomal locations. Of the three gene clusters, trpE(G), trpDC, and trpFBA, only… Expand
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