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Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica
Abstract A hot water extract from the fruit of Hyphaene thebaica was examined for its (i) hydrogen donating activity, (ii) Fe2+-chelating activity, (iii) hydroxyl radical-scavenging activity, (iv)…
Insights into opioid action in the intestinal tract.
Insights into mechanisms of opioid antidiarrhoeal action now provide some new perspectives of opioid action in the intestine and highlights and contrasts the similarities and differences in the commonly examined species and compare them to humans.
Activation of 5‐HT3 receptors in the rat and mouse intestinal tract: a comparative study
It is concluded that functional 5‐ HT3 receptors are present in nerves along the length of the rat and mouse intestinal tract and the mouse proximal colon was found to discriminate 5‐HT3 receptor agonist profiles better than any other region in the rat or mouse.
Characterisation of a postjunctional 5-ht7-like and a prejunctional 5-HT3 receptor mediating contraction of rat isolated jejunum.
It is suggested that rat jejunum contains a neuronal 5-HT3 receptor facilitating neurokinin release and a contractile smooth muscle 5- HT receptor with a pharmacological operational profile similar to the cloned 5-ht7 receptor.
Comparison of opioid receptor distributions in the rat central nervous system.
The appearance of a separate population of kappa-expressing cells supports proposals that the contrasting and functionally antagonistic properties of mu and kappa receptors are due to expression in physiologically distinct cell types.
A comparative study of functional 5‐HT4 receptors in human colon, rat oesophagus and rat ileum
The studies have shown that the human colon, rat oesophagus and rat ileum contain functional 5‐HT4 receptors and the 5‐ HT4 receptor agonists displayed differences in these tissues making it to be cautious when extrapolating from animal to human tissue.
Human 5–HT4 and 5–HT7 Receptor Splice Variants: Are they Important?
This review examines the functional relevance and known and candidate signalling systems that allow for splice variant specific responses include GPCR interacting proteins (GIPs) and G PCR receptor kinases (GRKs) which are examined.
Demonstration of 5-HT3 receptor function and expression in the mouse bladder
- N. Chetty, I. Coupar, R. Chess-Williams, K. Kerr
- Chemistry, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 3 July 2007
5-HT mediates enhanced neurogenic contractions of the mouse bladder muscle by an action at 5-HT3 receptors located prejunctionally on nonsensory nerve elements.
Characterization and tissue location of the neural adenosine receptor in the rat ileum
- I. Coupar
- Biology, MedicineBritish journal of pharmacology
- 1 March 1999
The rat ileum contains inhibitory A1 adenosine receptors situated on cholinergic nerve endings innervating the circular muscle, as well as potent agonists previously tested in the rat jejunum peristaltic reflex preparation.
Involvement of alpha-2 adrenoceptors in the effects of moxonidine on intestinal motility and fluid transport.
The effects of moxonidine in mediating inhibition of intestinal motility and enhancing fluid transport are attributed predominantly to interaction with alpha-2 adrenoceptors.