I. Cook

Publications128
h-index29
Citations2,570
Highly Influential Citations87
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Predictors of Outcome in an Open Label, Therapeutic Trial of High-Dose Omeprazole in Laryngitis
BACKGROUND:Gastroesophageal reflux is implicated in some cases of laryngitis. There are no established predictors of response to acid suppression therapy in suspected reflux laryngitis.AIM:In a… Expand
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Prolonged multi-point recording of colonic manometry in the unprepared human colon: providing insight into potentially relevant pressure wave parameters
OBJECTIVES:To determine the feasibility of and derive normative data for prolonged, 24-h, multipoint, closely spaced, water perfused manometry of the unprepared human colon.METHODS:In 14 healthy… Expand
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Sacral nerve stimulation induces pan‐colonic propagating pressure waves and increases defecation frequency in patients with slow‐transit constipation
Objective  Colonic propagating sequences are important for normal colonic transit and defecation. The frequency of these motor patterns is reduced in slow‐transit constipation. Sacral nerve… Expand
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Low‐resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: Initial results from fiber‐optic high‐resolution manometry studies
High‐resolution manometry catheters are now being used to record colonic motility. The aim of this study was to determine the influence of pressure sensor spacing on our ability to identify colonic… Expand
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Twenty‐four hour spatiotemporal mapping of colonic propagating sequences provides pathophysiological insight into constipation
Abstract  Colonic propagating sequences (PS)s are a major determinant of luminal propulsion. A global appreciation of spatiotemporal patterning of PSs requires evaluation of 24 h pan‐colonic… Expand
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Sacral Nerve Stimulation Fails to Offer Long-term Benefit in Patients With Slow-Transit Constipation
BACKGROUND: Sacral nerve stimulation is proposed as a treatment for slow-transit constipation. However, in our randomized controlled trial we found no therapeutic benefit over sham stimulation. These… Expand
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Spatial and temporal organization of pressure patterns throughout the unprepared colon during spontaneous defecation
OBJECTIVE:The aim of this study was to examine colonic motor events associated with spontaneous defecation in the entire unprepared human colon under physiological conditions.METHODS:In 13 healthy… Expand
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Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation.
BACKGROUND & AIMS The pathophysiology of constipation in the syndrome of obstructed defecation is unknown. Using 24-hour pancolonic manometric recordings of the unprepared colon to record basal… Expand
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Proximal colonic propagating pressure waves sequences and their relationship with movements of content in the proximal human colon
Abstract  Abnormal colonic motor patterns have been implicated in the pathogenesis of severe constipation. Yet in health, the mechanical link between movement of colonic content and regional… Expand
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Treatment Efficacy of Sacral Nerve Stimulation in Slow Transit Constipation: A Two-Phase, Double-Blind Randomized Controlled Crossover Study
Objectives:Sacral nerve stimulation (SNS) is a potential treatment for constipation refractory to standard therapies. However, there have been no randomized controlled studies examining its efficacy.… Expand
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