• Publications
  • Influence
Asymmetric deprotonation of N-boc piperidine: react IR monitoring and mechanistic aspects.
The high yielding asymmetric deprotonation trapping of N-Boc piperidine is successfully realized using s-BuLi and a (+)-sparteine surrogate. Monitoring of the lithiation by in situ React IR allowedExpand
  • 111
  • 1
Synthesis and biological studies of 1-amino β-carbolines
A selection of 1-amino-substituted β-carbolines have been prepared by amination of 1-chloro-β-carboline as simple mimics of manzamine A and chloroquine and their intercalating ability, anticancer andExpand
  • 61
  • 1
Dynamic thermodynamic and dynamic kinetic resolution of 2-lithiopyrrolidines.
Dynamic resolution has been studied as a method for the asymmetric synthesis of 2-substituted pyrrolidines. Highly enantioselective electrophilic substitutions of racemic 2-lithiopyrrolidines in theExpand
  • 50
  • 1
Asymmetric deprotonation of N-Boc-piperidines
Abstract A selection of chiral ligands was screened for the asymmetric deprotonation of N-Boc-piperidine. The asymmetric deprotonation of this compound is notoriously difficult and reasonable yieldsExpand
  • 36
  • 1
Dynamic resolution of N-Boc-2-lithiopiperidine.
Dynamic thermodynamic resolution of N-Boc-2-lithiopiperidine is possible using a chiral ligand; the two enantiomers of this organolithium can be resolved with selectivities of up to 85 : 15 from aExpand
  • 23
  • 1
  • PDF
Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine.
Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin-lithium exchange) and is resolvedExpand
  • 16
  • 1
  • PDF
Intramolecular dipolar cycloaddition reactions of azomethine ylides.
It was in 1963 that Huisgen laid out the classification of 1,3-dipoles and the concepts for 1,3-dipolar cycloaddition reactions, although it was not until 1976 that the first intramolecularExpand
  • 672
  • PDF
An experimental and in situ IR spectroscopic study of the lithiation-substitution of N-Boc-2-phenylpyrrolidine and -piperidine: controlling the formation of quaternary stereocenters.
A general and enantioselective synthesis of 2-substituted 2-phenylpyrrolidines and -piperidines, an important class of pharmaceutically relevant compounds that contain a quaternary stereocenter, hasExpand
  • 64