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KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode… Expand
Identification of Two Nervous System-Specific Members of theerg Potassium Channel Gene Family
- W. Shi, R. S. Wymore, +4 authors J. Dixon
- Biology, Medicine
- The Journal of Neuroscience
- 15 December 1997
Two new potassium channel genes, erg2 anderg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG)… Expand
Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current.
The expression of 15 different K+ channels in canine heart was examined, and a new K+ channel gene (Kv4.3), which encodes a rapidly inactivating K+ current, is described. The Kv4.3 channel was found… Expand
Regulation of KChIP2 potassium channel β subunit gene expression underlies the gradient of transient outward current in canine and human ventricle
Expression of four members of the KChIP family of potassium channel β subunits was examined in canine heart. Only one member of the gene family, KChIP2, was expressed in heart. There was a steep… Expand
Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues.
HCN cation channel mRNA expression was determined in the rabbit heart and neonatal and adult rat ventricle using RNase protection assays. In the rabbit SA node, the dominant HCN transcript is HCN4,… Expand
Connexin‐specific cell‐to‐cell transfer of short interfering RNA by gap junctions
- V. Valiunas, Y. Y. Polosina, +8 authors P. Brink
- Biology, Medicine
- The Journal of physiology
- 1 October 2005
The purpose of this study was to determine whether oligonucleotides the size of siRNA are permeable to gap junctions and whether a specific siRNA for DNA polymerase β (pol β) can move from one cell… Expand
Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model
- J. Williams, Jianjin Xu, +5 authors E. Entcheva
- Biology, Computer Science
- PLoS Comput. Biol.
- 1 September 2013
A quantitative model of Channelrhodospin-2, a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology. Expand
Human Mesenchymal Stem Cells as a Gene Delivery System to Create Cardiac Pacemakers
Abstract— We tested the ability of human mesenchymal stem cells (hMSCs) to deliver a biological pacemaker to the heart. hMSCs transfected with a cardiac pacemaker gene, mHCN2, by electroporation… Expand
Human mesenchymal stem cells make cardiac connexins and form functional gap junctions
Human mesenchymal stem cells (hMSCs) are a multipotent cell population with the potential to be a cellular repair or delivery system provided that they communicate with target cells such as cardiac… Expand
Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro
We investigated effects of the paracrine factors secreted by human mesenchymal stem cells (hMSCs) on endothelial cell migration, extracellular matrix invasion, proliferation, and survival in vitro.… Expand