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The ADAMTS metalloproteinases.
The ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was firstExpand
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The regulation of matrix metalloproteinases and their inhibitors.
The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECMExpand
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Expression profiling of metalloproteinases and their inhibitors in cartilage.
OBJECTIVE To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage andExpand
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Matrix metalloproteinases in arthritic disease
Chapter summary The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development ofExpand
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Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.
OBJECTIVE To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs),Expand
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The cartilage specific microRNA‐140 targets histone deacetylase 4 in mouse cells
MicroRNAs (miRNA) are short RNA molecules regulating the expression of specific mRNAs. We investigated the expression pattern and potential targets of mouse miR‐140 and found that miR‐140 isExpand
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Hypoxia promotes fibrogenesis in human renal fibroblasts.
BACKGROUND The mechanisms underlying progressive renal fibrosis are unknown, but the common association of fibrosis and microvascular loss suggests that hypoxia per se may be a fibrogenic stimulus.Expand
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The role of chondrocyte senescence in osteoarthritis
Replicative senescence occurs when normal somatic cells stop dividing. Senescent cells remain viable, but show alterations in phenotype, e.g. altered expression of matrix metalloproteinases (MMPs);Expand
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The expression and function of microRNAs in chondrogenesis and osteoarthritis.
OBJECTIVE To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with a functional role in cartilage homeostasis. METHODS The expression of miRNAs was measured in the ATDC5 cellExpand
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Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, and enzymes fromExpand
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