• Publications
  • Influence
Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
  • I. Chopra, Marilyn Roberts
  • Biology, Medicine
  • Microbiology and Molecular Biology Reviews
  • 1 June 2001
Changing the use of tetracyclines in human and animal health as well as in food production is needed if this class of broad-spectrum antimicrobials through the present century is to continue to be used. Expand
The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?
  • I. Chopra
  • Medicine
  • The Journal of antimicrobial chemotherapy
  • 1 April 2007
The clinical incidence of silver resistance remains low, and emergence of resistance can be minimized if the level of silver ions released from products is high and the bactericidal activity rapid. Expand
Organic acids: chemistry, antibacterial activity and practical applications.
The chapter discusses two aspects of the use of organic acids: in animal husbandry as animal feed additives and in abattoirs and food-processing plants where they may be used in controlling microbial contamination of carcass meat. Expand
Tetracyclines, molecular and clinical aspects.
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
Despite some drawbacks, membrane-active agents form an important new means of eradicating recalcitrant, non-growing bacteria. Expand
Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents
Recent novel findings in the laboratory suggest that AaRS could represent therapeutic targets where the loss of fitness associated with resistance could be compatible with antimicrobial restriction policies to eliminate resistance. Expand
Characterization of the Epidemic European Fusidic Acid-Resistant Impetigo Clone of Staphylococcus aureus
The EEFIC strains exhibited resistance to fusidic acid, penicillin, and, in some cases, erythromycin, which are all used in the treatment of impetigo and has been designated SaRIfusB (for “S. aureus resistance island carrying fusB”). Expand
Molecular basis of fusB‐mediated resistance to fusidic acid in Staphylococcus aureus
The cloning, sequencing and overexpression of a single gene (fusB) from plasmid pUB101 capable of conferring resistance to fusidic acid in S. aureus are reported and the purified protein shown to protect an in vitro staphylococcal translation system from inhibition by fusids acid in a specific and dose‐dependent fashion. Expand
Understanding antibacterial action and resistance
Impact on society of bacterial resistance to antibiotics and biocides and ways of counteracting it. Expand
Short-chain organic acids at ph 5.0 kill Escherichia coli and Salmonella spp. without causing membrane perturbation.
Cell death was not associated with a reduction in culture turbidity or a loss of membrane integrity since morphologically normal membranes were observed by electron microscopy and only a small proportion of the cytoplasmic enzyme beta-galactosidase leaked into the supernatant fluid of acid-treated E. coli K12 cultures. Expand