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Turmeric and curcumin: Biological actions and medicinal applications
TLDR
Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects, and have the potential for the development of modern medicine for the treatment of various diseases. Expand
Biological activities and medicinal properties of neem (Azadirachta indica)
TLDR
This review gives a bird’s eye view mainly on the biological activities of some of the neem compounds isolated, pharmacological actions ofThe neem extracts, clinical studies and plausible medicinal applications of neem along with their safety evaluation. Expand
A Novel Antioxidant and Antiapoptotic Role of Omeprazole to Block Gastric Ulcer through Scavenging of Hydroxyl Radical*
TLDR
Omeprazole plays a significant role in gastroprotection by acting as a potent antioxidant and antiapoptotic molecule. Expand
Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen.
TLDR
It is suggested that curcumin protects gastric damage by efficient removal of H( 2)O(2) and H (2)O-derived ()OH by preventing peroxidase inactivation by indomethacin. Expand
Gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H(+)-K(+)-ATPase inhibition and scavenging of hydroxyl radical.
TLDR
Bark extract is more effective than melatonin, vitamin E, desferrioxamine and alpha-phenyl N-tert butylnitrone, the known antioxidants having antiulcer effect and well tolerated by rats with no significant adverse effect. Expand
Molecular diagnosis of Wilson disease using prevalent mutations and informative single-nucleotide polymorphism markers.
TLDR
Sets of SNP markers are highly heterozygous across most world populations and could be used in combination with analysis of prevalent mutations as a comprehensive strategy for determining presymptomatic and carrier sibs of WD patients. Expand
A novel COMMD1 mutation Thr174Met associated with elevated urinary copper and signs of enhanced apoptotic cell death in a Wilson Disease patient
TLDR
In a patient showing apoptotic symptoms and high urinary copper surpassing normal WD levels, a novel, putative mutation in COMMD1 is identified and genotype-phenotype correlation between the detected changes and the atypical presentation of the WD patient is examined. Expand
Molecular Pathogenesis of Wilson Disease Among Indians: A Perspective on Mutation Spectrum in ATP7B gene, Prevalent Defects, Clinical Heterogeneity and Implication Towards Diagnosis
TLDR
Genotype–phenotype correlation revealed that no particular phenotype could be assigned to a particular mutation and even same set of mutations in different patients showed different phenotypes, suggesting high genetic heterogeneity and the absence of a single or a limited number of common founder mutations. Expand
Genetic landscape of the people of India: a canvas for disease gene exploration
TLDR
High levels of genetic divergence are observed between groups of populations that cluster largely on the basis of ethnicity and language in diverse populations of India. Expand
The Indian Genome Variation database (IGVdb): a project overview
TLDR
The structure of the IGV project is revealed highlighting its various aspects like genesis, objectives, strategies for selection of genes, identification of the Indian subpopulations, collection of samples and discovery and validation of genetic markers, data analysis and monitoring as well as the project’s data release policy. Expand
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