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In Vivo Mutations of Thymidylate Synthase (Encoded by thyA) Are Responsible for Thymidine Dependency in Clinical Small-Colony Variants of Staphylococcus aureus
It is demonstrated that mutations of the thyA gene were responsible for the phenotype of TD-SCVs and revealed that a functional ThyA protein is necessary and sufficient to change the SCV phenotype and behavior back to normal.
Microbial community and potential functional gene diversity involved in anaerobic hydrocarbon degradation and methanogenesis in an oil sands tailings pond.
The metagenomic dataset indicated the presence of genes involved in the three stages of anaerobic aromatic hydrocarbon degradation, including genes for enzymes of the peripheral, the central, and the methanogenesis pathways.
Characterization of Clinical Enterococcus faecalis Small-Colony Variants
- N. Wellinghausen, I. Chatterjee, A. Berger, A. Niederfuehr, R. Proctor, B. Kahl
- BiologyJournal of Clinical Microbiology
- 15 July 2009
The observed structural alterations and changes in the cellular growth and metabolic pathways facilitated the survival of Enterococcus SCVs under microaerobic conditions in vitro and thus presumably in vivo during endocarditis.
Mechanisms of biofilm formation in Staphylococcus epidermidis and Staphylococcus aureus: functional molecules, regulatory circuits, and adaptive responses.
Staphylococcus aureus ClpC Is Required for Stress Resistance, Aconitase Activity, Growth Recovery, and Death
ClpC inactivation abolished post-stationary-phase recovery but also resulted in significantly enhanced stationary-phase survival compared to that of the wild-type strain, demonstrating the critical role of the ClpC ATPase in regulating the TCA cycle and implicate clpC as being important for recovery from the stationary phase and also for entering the death phase.
The Caenorhabditis elegans spe-38 gene encodes a novel four-pass integral membrane protein required for sperm function at fertilization
In antibody localization experiments, SPE-38 was found to concentrate on the pseudopod of mature sperm, consistent with it playing a direct role in gamete interactions, and predicted to encode a novel four-pass (tetraspan) integral membrane protein.
Very Low Ethanol Concentrations Affect the Viability and Growth Recovery in Post-Stationary-Phase Staphylococcus aureus Populations
- I. Chatterjee, G. Somerville, C. Heilmann, H. Sahl, H. Maurer, M. Herrmann
- BiologyApplied and Environmental Microbiology
- 1 April 2006
Data demonstrate that VLEC have profound effects on the recovery of S. aureus even after ethanol depletion and delay the transition from primary to secondary metabolite catabolism, and suggest that the concentration of ethanol needed for bacteriostatic control ofS.
Staphylococcus aureus ClpC ATPase is a late growth phase effector of metabolism and persistence
This study provides strong evidence for ClpC as a critical factor in staphylococcal energy metabolism, stress regulation, and late‐stationary phase survival; therefore, these data provide important insight into the adaptation of S. aureus toward a persister state in chronic infections.
Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Associated with Extensive Alterations in Regulator and Virulence Gene Expression Profiles
Multiple changes in growth characteristics and in regulator and virulence gene expression render SCVs less virulent and allow them to survive in the hostile environment present in the airways of CF patients, thereby illustrating adaptation of the bacteria during long-term persistence.