Author pages are created from data sourced from our academic publisher partnerships and public sources.
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
The ability of human immunodeficiency virus (HIV-1) to persist and cause AIDS is dependent on its avoidance of antibody-mediated neutralization. The virus elicits abundant, envelope-directed… Expand
Interpreting complex binding kinetics from optical biosensors: a comparison of analysis by linearization, the integrated rate equation, and numerical integration.
The binding kinetics recorded for many interactions using BIAcore and IAsys optical biosensors do not fit a simple bimolecular interaction model (A + B<-->AB). Three methods of analysis have been… Expand
The complete amino acid sequence of papain. Additions and corrections.
Abstract The active cysteine of papain was labeled with 14C-iodoacetate and the cystine residues were reduced and coupled with unlabeled iodoacetate. The heptacarboxymethyl papain was then… Expand
Nature of the charged-group effect on the stability of the C-peptide helix.
- Kevin R. Shoemaker, P. Kim, +5 authors R. Baldwin
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 April 1985
The residues responsible for the pH-dependent stability of the helix formed by the isolated C-peptide (residues 1-13 of ribonuclease A) have been identified by chemical synthesis of analogues and… Expand
Controlled formation of model homo- and heterodimer coiled coil polypeptides.
Sequence-simplified coiled coil polypeptides were synthesized and their folding properties characterized in order to define the role of charged border residues at the coiled coil interface for the… Expand
Molecular properties of the oxytocin/bovine neurophysin biosynthetic precursor. Studies using a semisynthetic precursor.
An oxytocin/bovine neurophysin I biosynthetic precursor, [N epsilon-diacetimidyl-30,71, des-His106]pro-OT/BNPI, was synthesized from a synthetic oxytocinyl peptide,… Expand
Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design.
Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing number… Expand
Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization
- X. Yang, Inna Lipchina, S. Cocklin, I. Chaiken, J. Sodroski
- Biology, Medicine
- Journal of Virology
- 6 September 2006
ABSTRACT Primary and laboratory-adapted variants of human immunodeficiency virus type 1 (HIV-1) exhibit a wide range of sensitivities to neutralization by antibodies directed against the viral… Expand
Interdomain communication of T-cell CD4 studied by absorbance and fluorescence difference spectroscopy measurements of urea-induced unfolding.
- S. W. Tendian, D. Myszka, R. Sweet, I. Chaiken, C. Brouillette
- Chemistry, Medicine
- 16 May 1995
CD4 is a transmembrane glycoprotein expressed on T-lymphocytes. It is a receptor for class II major histocompatibility complex (MHC) molecules and for the HIV envelope glycoprotein gp120. The… Expand