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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
The ability of human immunodeficiency virus (HIV-1) to persist and cause AIDS is dependent on its avoidance of antibody-mediated neutralization. The virus elicits abundant, envelope-directedExpand
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Interpreting complex binding kinetics from optical biosensors: a comparison of analysis by linearization, the integrated rate equation, and numerical integration.
The binding kinetics recorded for many interactions using BIAcore and IAsys optical biosensors do not fit a simple bimolecular interaction model (A + B<-->AB). Three methods of analysis have beenExpand
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Analytical Affinity Chromatography
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The complete amino acid sequence of papain. Additions and corrections.
Abstract The active cysteine of papain was labeled with 14C-iodoacetate and the cystine residues were reduced and coupled with unlabeled iodoacetate. The heptacarboxymethyl papain was thenExpand
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Nature of the charged-group effect on the stability of the C-peptide helix.
The residues responsible for the pH-dependent stability of the helix formed by the isolated C-peptide (residues 1-13 of ribonuclease A) have been identified by chemical synthesis of analogues andExpand
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Controlled formation of model homo- and heterodimer coiled coil polypeptides.
Sequence-simplified coiled coil polypeptides were synthesized and their folding properties characterized in order to define the role of charged border residues at the coiled coil interface for theExpand
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Molecular properties of the oxytocin/bovine neurophysin biosynthetic precursor. Studies using a semisynthetic precursor.
An oxytocin/bovine neurophysin I biosynthetic precursor, [N epsilon-diacetimidyl-30,71, des-His106]pro-OT/BNPI, was synthesized from a synthetic oxytocinyl peptide,Expand
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Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design.
Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing numberExpand
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Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization
ABSTRACT Primary and laboratory-adapted variants of human immunodeficiency virus type 1 (HIV-1) exhibit a wide range of sensitivities to neutralization by antibodies directed against the viralExpand
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Interdomain communication of T-cell CD4 studied by absorbance and fluorescence difference spectroscopy measurements of urea-induced unfolding.
CD4 is a transmembrane glycoprotein expressed on T-lymphocytes. It is a receptor for class II major histocompatibility complex (MHC) molecules and for the HIV envelope glycoprotein gp120. TheExpand
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