I. Castillo

Publications125
h-index32
Citations3,193
Highly Influential Citations111
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Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown.
BACKGROUND There are patients in whom the etiology of long-standing abnormal results of liver-function tests is unknown (ALF-EU) after exclusion of all known causes of liver diseases. We analyzed the… Expand
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Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection
Background: Occult hepatitis C virus (HCV) infection is characterised by the presence of HCV-RNA in the liver in the absence of anti-HCV, and serum viral RNA. Up to 70% of these patients also have… Expand
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Occult hepatitis C virus infection among hemodialysis patients.
Occult hepatitis C virus (HCV) infection (i.e., detectable HCV-RNA in the liver or peripheral blood mononuclear cells) in the absence of both serum HCV-RNA and anti-HCV antibodies has not been… Expand
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Hepatitis C virus replicates in the liver of patients who have a sustained response to antiviral treatment.
BACKGROUND Positive-strand hepatitis C virus (HCV) RNA has been detected in the livers of patients who have achieved a sustained biochemical and virological response to antiviral therapy (hereafter,… Expand
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New perspectives in occult hepatitis C virus infection.
Occult hepatitis C virus (HCV) infection, defined as the presence of HCV RNA in liver and in peripheral blood mononuclear cells (PBMCs) in the absence of detectable viral RNA in serum by standard… Expand
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Genetic Diversity and Tissue Compartmentalization of the Hepatitis C Virus Genome in Blood Mononuclear Cells, Liver, and Serum from Chronic Hepatitis C Patients
ABSTRACT The degree of genetic variability in the hypervariable region 1 of hepatitis C virus (HCV) was analyzed by cloning and sequencing HCV genomes obtained in paired samples of serum, liver… Expand
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Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) Can Coinfect the Same Hepatocyte in the Liver of Patients with Chronic HCV and Occult HBV Infection
ABSTRACT In this work, we have shown that hepatitis C virus (HCV) and hepatitis B virus (HBV) can coexist in the same hepatocyte using double fluorescent in situ hybridization in liver biopsy samples… Expand
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Distribution of hepatitis B virus in the liver of chronic hepatitis C patients with occult hepatitis B virus infection
Although occult hepatitis B virus (HBV) infection (HBV‐DNA in serum in the absence of hepatitis B surface antigen [HBsAg]) is common in chronic hepatitis C, its characteristics are not well known. In… Expand
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Diagnosis of occult hepatitis C without the need for a liver biopsy
The diagnosis of occult hepatitis C virus (HCV) infection is based on the presence of HCV‐RNA in the liver. This study aimed to evaluate the use of combining non‐invasive assays to diagnose occult… Expand
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Hepatitis C virus infection in the family setting of patients with occult hepatitis C
Family members of patients with chronic hepatitis C virus (HCV) infection are at increased risk of HCV infection but the prevalence of HCV among family members of patients with occult HCV infection… Expand
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