• Publications
  • Influence
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103+ dermal subset. We examined their involvement in the presentation of skin-associatedExpand
  • 636
  • 39
  • PDF
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.
A novel dendritic cell (DC)-restricted molecule, Clec9A, was identified by gene expression profiling of mouse DC subtypes. Based on sequence similarity, a human ortholog was identified. Clec9AExpand
  • 387
  • 18
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells
Spleen-resident dendritic cell (DC) populations occupy sentinel positions for the capture and presentation of blood-borne antigens. Here we found a difference in expression of the chemotacticExpand
  • 121
  • 16
CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen
CD103-expressing dendritic cells in the lungs preferentially take up and cross-present antigen from apoptotic cells.
  • 260
  • 14
  • PDF
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
Improved protein-based vaccines should facilitate the goal of effective vaccines against HIV and other pathogens. With respect to T cells, the efficiency of immunization, or “immunogenicity,” isExpand
  • 244
  • 12
  • PDF
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
The immune system must distinguish viable cells from cells damaged by physical and infective processes. The damaged cell-recognition molecule Clec9A is expressed on the surface of the mouse and humanExpand
  • 247
  • 11
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Three surface molecules of mouse CD8+ dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy forExpand
  • 168
  • 10
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells.
The capacity of mouse spleen conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs) to produce interferon-gamma (IFN-gamma) or IFN-alpha was assessed, and compared with that ofExpand
  • 148
  • 10
C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription
Interleukin 12 (IL-12) is a 70-kD proinflammatory cytokine produced by antigen presenting cells that is essential for the induction of T helper type 1 development. It comprises 35-kD (p35) and 40-kDExpand
  • 194
  • 8
  • PDF