• Publications
  • Influence
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.
TLDR
The cloned genes should help to elucidate the molecular basis for indolocarbazole biosynthesis and set the stage for the generation of novel indolo-rebeccamycin analogues by genetic engineering. Expand
On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids.
  • I. Butovich
  • Medicine, Biology
  • Investigative ophthalmology & visual science
  • 1 September 2008
TLDR
Data showed that lipids in AT are more complex than MG secretions, which necessitates more cautious interpretation of the functions of the latter in the tear film. Expand
Understanding and Analyzing Meibomian Lipids—A Review
TLDR
The advantages and disadvantages of various collection and storage techniques are described, as well as how gas chromatography and combined HPLC and mass spectrometry coupled with fragmentation are currently enabling to determine the nature of the lipids in very small samples. Expand
Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum
TLDR
Due to their amphiphilic anionogenic nature, OAHFAs may be responsible for stabilization of the tear film lipid layer by creating an interface between the vast pool of strictly nonpolar lipids of meibum (WEs, cholesteryl esters, etc.) and the aqueous subphase beneath it, a role previously attributed to phospholipids. Expand
The Meibomian Puzzle: Combining pieces together
  • I. Butovich
  • Chemistry, Medicine
  • Progress in Retinal and Eye Research
  • 1 November 2009
TLDR
The most intriguing development is the virtual absence in meibum of typical phospholipids - an important group of amphiphilic compounds whose role in the human tear film was thought to be to stabilize the entire tear film structure. Expand
Tear film lipids.
  • I. Butovich
  • Chemistry, Medicine
  • Experimental eye research
  • 1 December 2013
TLDR
The purpose of this review is to discuss recent results that were obtained using different experimental techniques, estimate limitations of their usability, and discuss their biochemical, biophysical, and physiological implications. Expand
Lipids of human meibum: mass-spectrometric analysis and structural elucidation1 Published, JLR Papers in Press, July 12, 2007.
TLDR
Observations suggest that MGS are a major source of nonpolar lipids of the THE AUTHORS and Chl-E families for the tear film lipid layer, but not of its previously reported (phospho)lipid, Cer, and fatty acid amide components. Expand
The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease.
TLDR
The meibomian gland's contribution to TF lipids and lipid-binding proteins and lipid–protein interactions in health and disease are examined to examine their relationship with disease and TF stability. Expand
12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis
TLDR
A large collection of experimental data suggest that 12(S)-HETE is a crucial intracellular signaling molecule that activates protein kinase C and mediates the biological functions of many growth factors and cytokines such as bFGF, PDGF, EGF, and AMF, and the rationale for targeting these molecules in anti-cancer and anti-metastasis therapeutic protocols. Expand
Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4
TLDR
The generated Stgd3-knockin mice are a genetic model of human STGD3 and reproduce features of the human disease: accumulation of lipofuscin and reduced visual functions. Expand
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