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Genotoxicity of quercetin in cultured mammalian cells.
The naturally occurring flavonol, quercetin, was investigated concerning its ability to induce SCEs and HGPRT-deficient mutants in V79 Chinese hamster cells, and HGPRT- and TK-deficient mutants inExpand
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Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate.
Ally isothiocyanate has been reported to be a bladder carcinogen in male rats. On the other hand, benzyl isothiocyanate is an anti-carcinogen. These contradicting properties led us to investigate theExpand
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Cytomorphological changes in liver cells exposed to allyl and benzyl isothiocyanate and their cysteine and glutathione conjugates
Since allyl isothiocyanate has been reported to be a bladder carcinogen and benzyl isothiocyanate is a known anti-carcinogen, it is important to know the mode of their cytotoxic action. This wasExpand
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The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study.
Hexachlorobenzene (HCB) induces a broad spectrum of effects including disturbances in the heme synthesis (porphyria) and in thyroid hormone homeostasis. For most of its effects, biotransformation ofExpand
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Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands.
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The killifish Nothobranchius rachowi, a new animal in genetic toxicology.
Nothobranchius rachowi, a tropical fish that belongs to the family of the Cyprinodontidae, is introduced as a new animal for genetic toxicological studies. The karyotype of N. rachowi consists of 16Expand
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Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies.
Kidney cells were isolated from rat kidney cortex and maintained in short-term monolayer cultures. A number of important parameters were studied in order to establish the usefulness of these cellsExpand
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Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells.
Genotoxicity of emodin was studied in the Salmonella/microsome assay, the sister-chromatid exchange (SCE) assay and the hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) forward mutation assayExpand
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Comparative toxicity and accumulation of cadmium chloride and cadmium-metallothionein in primary cells and cell lines of rat intestine, liver and kidney.
The protective role of metallothionein (Mt) in the toxicity of cadmium (Cd) is controversial, since Cd bound to Mt is more nephrotoxic than ionic Cd after parenteral exposure and less hepatotoxicExpand
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Effect of glutathione and cysteine on apical and basolateral uptake and toxicity of CdCl(2) in kidney cells (LLC-PK(1)).
LLC-PK(1) kidney cells were cultured on filters, to investigate both apical and basolateral uptake and concomitant toxicity of cadmium. Two to four times as much (109)CdCl(2) was taken up through theExpand
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