I. Brikun

Publications22
h-index11
Citations493
Highly Influential Citations21
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cysQ, a gene needed for cysteine synthesis in Escherichia coli K-12 only during aerobic growth
TLDR
Computer analyses revealed significant amino acid sequence homology between cysQ and suhB of E. coli and the gene for mammalian inositol monophosphatase, and it is proposed that CysQ helps control the pool of 3-phosphoadenoside 5'-phosphosulfate, or its use in sulfite synthesis.
Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum.
Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production.
Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea
TLDR
A metabolic model is proposed where in carbohydrate-based fermentations MCM acts as a drain on the methylmalonyl-CoA metabolite pool, and in oil- based fermentations,MCM acts in the reverse direction to fill the methyl malonyl -CoA pool.
Direct and crossover PCR amplification to facilitate Tn5supF-based sequencing of lambda phage clones.
TLDR
Direct and crossover PCR methods expedite transposon insertion mapping, and yield templates for accurate sequencing of both DNA strands.
DNA sequence divergence among derivatives of Escherichia coli K-12 detected by arbitrary primer PCR (random amplified polymorphic DNA) fingerprinting
TLDR
Comparison of RAPD polymorphisms and positions of strains exhibiting them in the pedigree suggests that many sequence changes occurred in these historic E. coli strains during their storage, and it is proposed that the clustering of such mutations near the terminus reflects errors during completion of chromosome replication.
A panel of DNA methylation markers for the detection of prostate cancer from FV and DRE urine DNA
TLDR
The results support the development of a non-invasive diagnostic test to reduce unnecessary biopsies in men with elevated PSA and provide patients with personalized recommendations based on their own methylation profile.
Analysis of CRP-CytR interactions at the Escherichia coli udp promoter
TLDR
The results support the model in which repression normally involves the binding of CytR to cAMP-CRP to form a complex which binds to specific sites in the udp promoter, and illustrates that only modest evolutionary changes could allow particular multiprotein complexes to serve as either repressors or transcriptional activators.
Direct and crossover PCR amplification to facilitate Tn5supF-based sequencing of λ phage clones
TLDR
Direct and crossover PCR methods expedite transposon insertion mapping, and yield templates for accurate sequencing of both DNA strands.
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum
TLDR
The gene order of the two ery clusters was conserved within a core region of 15 contiguous genes, with the exception of IS1136 which was not found in the A. erythreum cluster.
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