• Publications
  • Influence
Oxygen free radicals and metallothionein.
TLDR
The evidence supporting induction of metallothionein synthesis by oxidative stress, possible mediators for this induction, and the radical scavenging capability of met allothioneIn in tissues and cells are reviewed. Expand
Manifestations of copper excess.
  • I. Bremner
  • Chemistry, Medicine
  • The American journal of clinical nutrition
  • 1 May 1998
TLDR
Variations in the efficiency of the absorption and excretion of copper appear to reflect variations in the intake of other hepatotoxic or protective factors, differences in the cellular distribution of copper, and Differences in the expression of specific copper transport and storage proteins. Expand
Zinc, copper and manganese in the alimentary tract of sheep.
  • I. Bremner
  • Biology, Medicine
  • The British journal of nutrition
  • 1 September 1970
TLDR
The changes in the concentrations and solubilities of zinc, manganese and copper in the rumen, abomasum and along the small intestine of cannulated sheep, maintained on dried grass, have been determined and their relationship to the differences noted in the apparent requirements for trace elements of ruminants on different diets is discussed. Expand
The influence of dietary iron and molybdenum on copper metabolism in calves.
TLDR
The significance of the effects of Fe and Mo on Cu metabolism are discussed with special regard to the influence of soil ingestion on Cu availability and to the frequent lack of correlation between the Cu status of animals and their clinical condition. Expand
Obesity and hyperleptinemia in metallothionein (-I and -II) null mice.
TLDR
Observations indicate that abnormal accretion of body fat and adipocyte maturation is initiated at 5-7 weeks of age, possibly coincident with sexual maturation, providing a new obese animal model and a link between MT and the regulation of energy balance is implied. Expand
Metallothionein and the trace minerals.
TLDR
Etude de sa degradation, de ses fonctions dans la detoxication des metaux lourds, dans le controle de l'absorption intestinale, le metabolisme hepatique du zinc and du cuivre et de proteines de transfert. Expand
Iron-induced copper deficiency in calves: dose-response relationships and interactions with molybdenum and sulphur
The effects of dietary supplements of iron, molybdenum and sulphur on copper metabolism in calves were examined. In one experiment, 27 castrated male pre-ruminant Friesian calves were given aExpand
Involvement of metallothionein in the hepatic metabolism of copper.
  • I. Bremner
  • Biology, Medicine
  • The Journal of nutrition
  • 1987
TLDR
There is increasing evidence that MT plays an important role in the cellular detoxification of copper, although an involvement in the uptake, storage and transfer of copper has also been proposed. Expand
Nutritional and physiological significance of metallothionein.
  • I. Bremner
  • Chemistry, Medicine
  • Experientia. Supplementum
  • 1987
The biological function of metallothionein (MT) is still a matter of considerable conjecture. Convincing evidence has accrued that the protein can play an important role in the detoxification ofExpand
Copper and zinc metabolism in health and disease: speciation and interactions.
It has long been evident that the metabolism of trace elements cannot be considered in isolation. A wide range of nutritional and physiological factors can influence their uptake, transport andExpand
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