I. Beucler

Publications67
h-index21
Citations3,639
Highly Influential Citations110
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
TLDR
Two mutations in the gene PCSK9 (encoding proprotein convertase subtilisin/kexin type 9) that cause ADH are reported, a newly identified human subtilase that is highly expressed in the liver and contributes to cholesterol homeostasis.
Plant Sterol-Enriched Margarine Lowers Plasma LDL in Hyperlipidemic Subjects with low Cholesterol Intake: Effect of Fibrate Treatment
TLDR
It is concluded that phytosterol-enriched spread is a useful adjunctive therapy for hypercholesterolemic patients and a combination of fibrate treatment and plant sterol ester-supplemented spread offers a safe and effective measure to significantly decrease abnormally high cholesterol levels.
Smaller LDL particle size in women with polycystic ovary syndrome compared to controls
OBJECTIVE Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. The contribution of lipid abnormalities to this higher risk, in particular atherogenic…
Immunological detection of low-density lipoproteins modified by malondialdehyde in vitro or in vivo.
TLDR
Preliminary studies demonstrated that this ELISA technique allows the detection of lipoproteins containing malondialdehyde-modified apolipoprotein B in the serum of patients with cardiovascular diseases.
Low lipolytic enzyme activity in patients with severe hypertriglyceridemia on highly active antiretroviral therapy.
[Structure and metabolism of plasma lipoproteins].
TLDR
The composition and the pathway of the different lipoprotein classes (chylomicrons, VLDL, LDL, HDL, HDL) are reviewed, as also the main pathological perturbations that attack them.
Relationship between thyroid hormones and plasma D-dimer levels.
TLDR
The results suggest that fT 4 may play a physiological role in the regulation of the haemostatic equilibrium in hyperlipidemic patients and that low levels of fT4 are associated with a hypercoagulable state.
Infantile phytanic acid storage disease, a possible variant of Refsum's disease: Three cases, including ultrastructural studies of the liver
TLDR
Characteristics such as mental retardation, hepatomegaly, osteopenia, hypocholesterolaemia and hypoalphalipoproteinaemia, as well as the ultrastructural findings in the liver, suggested that the patients' illness was either a phytanic acid storage disease different from the classical form of Refsum's disease, or a more severe early symptomatic form ofrefsum’s disease.
Blood oxidative stress markers are unreliable markers of hepatic steatosis
Non‐alcoholic fatty liver disease (NAFLD) and viral hepatitis are associated with hepatic oxidative stress, which is partially dependent on the amount of hepatic fat.
APOE: A potential marker of disease progression in ALS
TLDR
APOE phenotype and plasma levels were measured in 403 patients with ALS and were correlated with clinical parameters and survival time, and APOE plasma levels appeared to be an important risk factor for decreased survival time.
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