Share This Author
Dissolution and bioavailability of lercanidipine-hydroxypropylmethyl cellulose nanoparticles with surfactant.
Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process
- Eun-Sol Ha, Jeong-Soo Kim, Min-Soo Kim
- Chemistry, Materials ScienceDrug design, development and therapy
- 4 August 2015
The results suggest that the preparation of megestrol acetate solid dispersion nanoparticles with a hydrophilic polymer and surfactant using the supercritical antisolvent process is a promising approach to improve the dissolution and absorption properties of megel acetate.
Preliminary Study Analyzing the Methylated Genes in the Plasma of Patients with Pancreatic Cancer
The detection of methylated genes in the plasma may have a role in differentiating between pancreatic cancers and healthy controls but not between pancreating cancer and chronic pancreatitis.
Preparation and Evaluation of Resveratrol-Loaded Composite Nanoparticles Using a Supercritical Fluid Technology for Enhanced Oral and Skin Delivery
HPMC/surfactant nanoparticles produced by an SAS process are a promising formulation method for trans-resveratrol for healthcare products (owing to their enhanced absorption via oral administration) and for skin application with cosmetic products.
Biopharmaceutical characterization of decursin and their derivatives for drug discovery
- Bimit Mahat, J. Chae, K. Kwon
- Biology, MedicineDrug development and industrial pharmacy
- 4 September 2013
Decursin, decursinol angelate and JH714 showed ratios of compound concentration in brain with respect to plasma (Cbrain/Cplasma) of >1.5, suggesting good brain/plasma ratio at 0.5 and inhibition of the CYP isoforms using Vivid® CYP screening kit.
Comparison of average, scaled average, and population bioequivalence methods for assessment of highly variable drugs: an experience with doxifluridine in beagle dogs.
Effect of food on the pharmacokinetics of rosuvastatin after administration of a single oral dose in dogs.
It is suggested that food intake affects both the rate and extent of absorption of rosuvastatin, and that rosuVastatin should be administered on an empty stomach to avoid food effect.
Preparation and evaluation of solid dispersion of atorvastatin calcium with Soluplus® by spray drying technique.
- Eun-Sol Ha, I. Baek, WonKyung Cho, Sung-Joo Hwang, Min-Soo Kim
- Biology, ChemistryChemical & pharmaceutical bulletin
- 1 June 2014
Spray-dried Soluplus® solid dispersions can be an effective method for achieving higher atorvastatin plasma levels and pharmacokinetic analysis in rats revealed that the 2 : 8 dispersion significantly improved the oral bioavailability of atorVastatin.
Characterization and therapeutic efficacy evaluation of glimepiride and L-arginine co-amorphous formulation prepared by supercritical antisolvent process: influence of molar ratio and preparation…