• Publications
  • Influence
Peripheral cannabinoid receptor, CB2, regulates bone mass.
  • O. Ofek, M. Karsak, +10 authors I. Bab
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 17 January 2006
The endogenous cannabinoids bind to and activate two G protein-coupled receptors, the predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid receptor type 2 (CB2). WhereasExpand
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Endocannabinoid signaling at the periphery: 50 years after THC.
In 1964, the psychoactive ingredient of Cannabis sativa, Δ(9)-tetrahydrocannabinol (THC), was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed endocannabinoidsExpand
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Hereditary hypophosphatemic rickets with hypercalciuria.
We studied a new hereditary syndrome of hypophosphatemic rickets and hypercalciuria in six affected members of one kindred. In all patients, the manifestations of disease began in early childhood.Expand
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The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
We have recently reported that in bone the cannabinoid CB1 receptor is present in sympathetic terminals. Here we show that traumatic brain injury (TBI), which in humans enhances peripheralExpand
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Oxytocin is an anabolic bone hormone
We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely to modulate lactation and social bonding, is a direct regulator of bone mass. Deletion of OT or the OTExpand
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Depression induces bone loss through stimulation of the sympathetic nervous system
Major depression is associated with low bone mass and increased incidence of osteoporotic fractures. However, causality between depression and bone loss has not been established. Here, we show thatExpand
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Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling
The CB1 cannabinoid receptor has been implicated in the regulation of bone remodeling and bone mass. A high bone mass (HBM) phenotype was reported in CB1-null mice generated on a CD1 backgroundExpand
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Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis.
Assessment of fracture healing is a common problem in orthopaedic practice and research. To determine the effectiveness of certain treatments, drugs, mechanical loads, or rehabilitation regimes, theExpand
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Pattern of gene expression following rat tibial marrow ablation
Following injury to bone marrow there is a phase of osteogenesis in which bone trabeculae replace the initial blood clot and fill the marrow cavity. The newly formed bone is subsequently fullyExpand
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