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o-nitrobenzyl photolabile protecting groups with red-shifted absorption: syntheses and uncaging cross-sections for one- and two-photon excitation.
The o-nitrobenzyl platform for designing photolabile protecting groups with red-shifted absorption that could be photolyzed upon one- and two-photon excitation is evaluated and the difficulty in enlarging the corresponding action uncaging cross-sections is emphasized in view of the observed trend of their quantum yield of uncaging. Expand
A caged retinoic acid for one- and two-photon excitation in zebrafish embryos.
Micelles of lipid-oligonucleotide conjugates: implications for membrane anchoring and base pairing.
This work uses UV-Vis absorption, steady-state fluorescence emission, electron microscopy, and fluorescence correlation spectroscopy after two-photon excitation to show that these DNA-lipids form spherical micelles in aqueous solution and incorporate much better in micells than in vesicles. Expand
Alcohol uncaging with fluorescence reporting: evaluation of o-acetoxyphenyl methyloxazolone precursors.
This paper evaluates a series of photolabile protecting groups with built-in fluorescence reporting that rely on readily available o-acetoxyphenyl methyloxazolones as activated precursors and quantitatively releases alcohol substrates in a 1:1 molar ratio. Expand
"Self-immolative" spacer for uncaging with fluorescence reporting.
Tridemethylisovelleral, a potent cytotoxic agent.
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining theExpand
Coumarinylmethyl caging groups with redshifted absorption.
The small and synthetically easily accessible coumarinylmethyl backbone has been modified to generate a family of photolabile protecting groups with redshifted absorption that is relevant for uncaging with cyan light and favorable to perform chromatic orthogonal photoactivation with UV and blue-cyan light sources. Expand
Synthesis and properties of water-soluble gold colloids covalently derivatized with neutral polymer monolayers.
Citrate-capped gold nanoparticles as well as planar gold surfaces can be efficiently grafted with a covalently attached polymer monolayer a few nanometers thick, by simple contact of the metalExpand
A blue-absorbing photolabile protecting group for in vivo chromatically orthogonal photoactivation.
The small and synthetically easily accessible 7-diethylamino-4-thiocoumarinylmethyl photolabile protecting group has been validated for uncaging with blue light. It exhibits a significant actionExpand