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Langerhans Cell Histiocytosis (LCH): Guidelines for Diagnosis, Clinical Work-Up, and Treatment for Patients Till the Age of 18 Years
These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated… Expand
Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis.
Langerhans cell histiocytosis (LCH)-III tested risk-adjusted, intensified, longer treatment of multisystem LCH (MS-LCH), for which optimal therapy has been elusive. Stratified by risk organ… Expand
Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study, with an estimated 5-year… Expand
Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis
To compare the capacity of the 2004 diagnostic guidelines for hemophagocytic lymphohistiocytosis (HLH‐2004) with the capacity of the preliminary diagnostic guidelines for systemic juvenile idiopathic… Expand
Use of Serological Markers as a Screening Test in Family Members of Patients with Celiac Disease
- J. C. Vitoria, A. Arrieta, I. Astigarraga, D. García-Masdevall, J. Rodríguez-soriano
- Journal of pediatric gastroenterology and…
- 1 October 1994
Summary: That symptomatic celiac disease (CD) can occur in several members of a family has long been recognized. Given the possible complications of untreated CD, it is also important to diagnose… Expand
Secondary central nervous system metastases in children with neuroblastoma.
- I. Astigarraga, R. Lejarreta, A. Navajas, A. Fernández-Teijeiro, I. Imaz, J. Bezanilla
- Medical and pediatric oncology
- 1 December 1996
Cerebral and meningeal involvement in patients with primary extracranial neuroblastoma (NB) is unusual although it is generally present in disseminated disease. The intensification of chemotherapy… Expand
Vincristine pharmacokinetics pathway and neurotoxicity during early phases of treatment in pediatric acute lymphoblastic leukemia.
- E. Lopez-Lopez, Á. Gutiérrez-Camino, +8 authors A. García-Orad
- Medicine, Biology
- 16 May 2016
AIM Vincristine is an important component of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from… Expand
Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte Society.
- S. Ehl, I. Astigarraga, +12 authors J. Henter
- The journal of allergy and clinical immunology…
- 1 September 2018
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome requiring aggressive immunosuppressive therapy. Following 2 large international studies mainly targeting… Expand
Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic…
Objective To develop and validate a diagnostic score that assists in discriminating primary hemophagocytic lymphohistiocytosis (pHLH) from macrophage activation syndrome (MAS) related to systemic… Expand
Hydrops fetalis and fibrosarcoma: case report of an uncommon association
- A. Navajas, I. Astigarraga, A. Fdez-Teijeiro, J. Lòpez-Heredia, B. Biritxinaga, C. Camarero
- European Journal of Pediatrics
- 29 June 1996
Abstract Fetal hydrops associated with neonatal tumours is an uncommon occurrence. The diagnosis can be established prenatally by ultrasound examination. The treatment of choice is surgery which may… Expand