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Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.
Cisplatin treatment induces extensive death of the proximal tubules in mice. We also demonstrated that treatment of immortalized mouse proximal tubule cells (TKPTS) with 25 microM cisplatin inducesExpand
Cisplatin nephrotoxicity.
Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeatedExpand
Combined Epstein‐Barr Virus and Human Papillomavirus Infection in Nasopharyngeal Carcinoma
Epstein‐Barr virus (EBV) has been shown to be a likely etiologic agent in nasopharyngeal carcinogenesis. Human papillomaviruses (HPVs) have previously been identified in numerous upper aerodigestiveExpand
Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc.
BACKGROUND Chronic nicotine (Ch-NIC) exposure exacerbates ischemia/reperfusion (I/R)-induced oxidative stress and acute kidney injury (AKI), and mitochondrial production of reactive oxygen speciesExpand
Activation of ERK or inhibition of JNK ameliorates H(2)O(2) cytotoxicity in mouse renal proximal tubule cells.
BACKGROUND Our previous studies suggest that the balance between the activation of extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal/stress-activated protein kinase (JNK) mightExpand
Clinical and molecular responses in high-grade intraepithelial neoplasia treated with topical imiquimod 5%.
OBJECTIVE To assess the clinical and molecular response of patients with recurrent high-grade vulvar, vaginal, or cervical intraepithelial neoplasia treated with topicalExpand
p66shc Inhibits Pro-survival Epidermal Growth Factor Receptor/ERK Signaling during Severe Oxidative Stress in Mouse Renal Proximal Tubule Cells*
The fully executed epidermal growth factor receptor (EGFR)/Ras/MEK/ERK pathway serves a pro-survival role in renal epithelia under moderate oxidative stress. We and others have demonstrated thatExpand
Unique microRNA expression profiles in cervical cancer.
Cervical cancer is the second leading cause of death among female patients with cancer in the world. Our aim was to analyze cervical cancer cases, in the Southwestern Transdanubian Region of Hungary,Expand
Gastrinomas Demonstrate Amplification of the HER‐2/neu Proto‐oncogene
ObjectiveThis study determined whether genomic amplification of HER-2/neu or mutations of the p53 and ras genes were present in gastrinomas. Summary Background DataAmplification of HER-2/neu, aExpand
Cisplatin induces apoptosis through the ERK-p66shc pathway in renal proximal tubule cells.
The extracellular signal-regulated kinase (ERK) has been shown to mediate cisplatin (CP)-induced toxicity to renal proximal tubule cells. Here, we demonstrate that ERK serves as the kinase thatExpand