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Amylin as a potential link between type 2 diabetes and alzheimer disease
TLDR
It is assessed whether tau and β‐amyloid deposits might be present in pancreatic tissue of subjects with AD, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of AD patients.
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Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies
TLDR
The presence of phosphorylated α-synuclein inclusions in pancreatic β cells provides a new evidence of a mechanism that is potentially common to the pathogenesis of diabetes mellitus, PD and DLB.
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Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein
TLDR
This study shows, for the first time, that along with amylin, pancreatic α-synuclein, Aβ, PrP and tau may contribute together to the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson’s disease.
View on Springer
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