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Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.
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Astrocyte–neuron metabolic relationships: for better and for worse
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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
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Lactate in the brain: from metabolic end-product to signalling molecule
TLDR
Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.
View on Nature
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
TLDR
L-lactate induces the expression of plasticity genes such as Arc, c-Fos, and Zif268 in neurons through a mechanism involving NMDA receptor activity and its downstream signaling cascade Erk1/2, revealing a previously unidentified action of l- lactate as a signaling molecule for neuronal plasticity.
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Methylglyoxal, the dark side of glycolysis
TLDR
A main emerging concept is that these two neural cell types have different and energetically adapted glyoxalase defense mechanisms which may serve as protective mechanism against methylglyoxal-induced cellular damage.
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Amyloid-β Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability
TLDR
A causal link between the effects of Aβ on glucose metabolism and its aggregation and internalization into astrocytes through binding to members of the class A scavenger receptor family could be demonstrated.
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Brain energy metabolism
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Modulation of astrocytic metabolic phenotype by proinflammatory cytokines
TLDR
Results establish that a proinflammatory environment such as observed in several neuropathological conditions including Alzheimer's disease, markedly modifies the metabolic phenotype of astrocytes.
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Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes
TLDR
Examination of the effects of fluoxetine on the expression of neurotrophic/growth factors that have antidepressant properties and on glucose metabolism in cultured cortical astrocytes suggests that, by increasing theexpression of specificAstrocyte-derived neurotrophic factors and lactate release from astroCytes, fluoxettine may contribute to normalize the trophic and metabolic support to neurons in major depression.
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