• Publications
  • Influence
Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.
The heat shock response maintains cellular homeostasis following sublethal injury. Heat shock proteins (Hsps) are induced by thermal, oxyradical, and inflammatory stress, and they chaperone denaturedExpand
  • 69
  • 5
  • PDF
Dickkopf Homologs in Squamous Mucosa of Esophagitis Patients Are Overexpressed Compared with Barrett's Patients and Healthy Controls
OBJECTIVES:Esophageal mucosal response to acid exposure varies from minimal changes to erosions/ulcerations and Barrett's metaplasia. While differences in acid contact time have been suggested, theExpand
  • 22
  • 2
Selective modulation of PKC isozymes by inflammation in canine colonic circular muscle cells.
BACKGROUND & AIMS Protein kinase C (PKC) is a key signaling molecule in excitation-contraction coupling in several types of smooth muscle cells. We investigated whether the attenuated contraction inExpand
  • 27
  • 1
Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-Like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide
Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.Expand
  • 12
  • 1
Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.
The capacity to follow cell type-specific signaling in intact lung remains limited. 20-hydroxyeicosatetraenoic acid (20-HETE) is an endogenous fatty acid that mediates signaling for a number of keyExpand
  • 9
  • 1
3-Hydroxy-4,7-megastigmadien-9-one, isolated from Ulva pertusa, attenuates TLR9-mediated inflammatory response by down-regulating mitogen-activated protein kinase and NF-κB pathways
Abstract Context: Seaweeds are rich in bioactive compounds in the form of vitamins, phycobilins, polyphenols, carotenoids, phycocyanins and polysaccharides; many of these are known to haveExpand
  • 7
  • 1
The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx.
The Cinchona bark contains alkaloids like quinine, quinidine, cinchonine and cinchonidine. These agents are effective antimalarial drugs and have been used clinically in malaria caused by PlasmodiumExpand
  • 19
Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats.
BACKGROUND We previously reported that the cytochrome P450 product 20-hydroxyeicosatetraenoic acid has prosurvival effects in pulmonary artery endothelial cells and ex vivo pulmonary arteries. WeExpand
  • 17
Intramucosal Distribution of WNT Signaling Components in Human Esophagus
Goals To determine expression and localization of Wnt signaling molecules across the esophageal mucosal thickness. Background The molecular mechanisms governing the biology and pathobiology ofExpand
  • 11
Resveratrol enhances mitomycin C-mediated suppression of human colorectal cancer cell proliferation by up-regulation of p21WAF1/CIP1.
BACKGROUND/AIM Studies have shown that natural products could potentially be employed in combination therapies to decrease toxicity to healthy tissues by chemotherapy drugs. No studies however, haveExpand
  • 19