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Cardioprotection by Intermittent Fasting in Rats
Background— Intermittent fasting (IF), a dietary regimen in which food is available only every other day, increases the life span and reduces the incidence of age-associated diseases in rodents. We… Expand
Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats
- Chanil Moon, Melissa Krawczyk, +4 authors M. Talan
- Proceedings of the National Academy of Sciences…
- 19 September 2003
Erythropoietin (EPO), well known for its role in stimulation of erythropoiesis, has recently been shown to have a dramatic neuroprotective effect in animal models of cerebral ischemia, mechanical… Expand
Cardioprotective and Survival Benefits of Long-Term Combined Therapy with β2 Adrenoreceptor (AR) Agonist and β1 AR Blocker in Dilated Cardiomyopathy Postmyocardial Infarction
- I. Ahmet, Melissa Krawczyk, +6 authors M. Talan
- Journal of Pharmacology and Experimental…
- 1 May 2008
We have reported therapeutic effectiveness of pharmacological stimulation of β2 adrenoreceptors (ARs) to attenuate the cardiac remodeling and myocardial infarction (MI) expansion in a rat model of… Expand
Beneficial Effects of Chronic Pharmacological Manipulation of &bgr;-Adrenoreceptor Subtype Signaling in Rodent Dilated Ischemic Cardiomyopathy
- I. Ahmet, Melissa Krawczyk, P. Heller, Chanil Moon, E. Lakatta, M. Talan
- 31 August 2004
Background—Studies in isolated cardiac myocytes have demonstrated that signaling via specific &bgr;1-adrenergic receptor subtypes (&bgr;1ARs) promotes but that signaling via &bgr;2ARs protects from… Expand
Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.
BACKGROUND A reduction of complexity of heart beating interval variability that is associated with an increased morbidity and mortality in cardiovascular disease states is thought to derive from the… Expand
Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.
- Ruiqian Wan, I. Ahmet, +4 authors M. Mattson
- The Journal of nutritional biochemistry
- 1 May 2010
It has been reported that dietary energy restriction, including intermittent fasting (IF), can protect heart and brain cells against injury and improve functional outcome in animal models of… Expand
Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway
Summary The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action remain to be determined. To augment cardiac fumarate levels and to… Expand
Effects of calorie restriction on cardioprotection and cardiovascular health.
- I. Ahmet, H. Tae, R. de Cabo, E. Lakatta, M. Talan
- Journal of molecular and cellular cardiology
- 1 August 2011
Multiple health benefits of calorie restriction (CR) and alternate day fasting (ADF) regimens are widely recognized. Experimental data concerning the effects of calorie restriction on cardiac health… Expand
A Small Nonerythropoietic Helix B Surface Peptide Based upon Erythropoietin Structure Is Cardioprotective against Ischemic Myocardial Damage
Strong cardioprotective properties of erythropoietin (EPO) reported over the last 10 years have been difficult to translate to clinical applications for ischemic cardioprotection owing to undesirable… Expand
Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy.
BACKGROUND We have reported that beta2 adrenoreceptor (beta2AR) stimulation is anti-apoptotic, and has strong beneficial effect on cardiac remodeling in an experimental model of post myocardial… Expand