I. Yu. Popova

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EEG traces were recorded from the hippocampus and medial septal area of conscious guinea pigs in control conditions and on repeated stimulation of the perforant path. Changes in the correlations of activity in these structures during stimulation-evoked convulsions (a model of acute epilepsy) and during the process of epileptogenesis (a model of chronic(More)
The effect of neuropeptides (TSKYR, TSKY and DY) and neurotransmitters (serotonin and noradrenaline) on the activity of medial septum (MS) neurons from the brain of summer wakening ground squirrels (WGS), hibernating ground squirrels (HGS), and hibernating ground squirrels with the undercut septum (UHGS) was studied. It was shown that in HGS, the(More)
Despite extensive interest in studies of the medial septal area, the nature of the interactions of its various neurochemical systems remains largely unclear. The aim of the present work was to clarify the role of nicotinic receptors in mediating the interaction of the glutamatergic and cholinergic systems in this structure. Extracellular recording of neuron(More)
Changes in the interactions of the hippocampus and medial septal area in the theta range (4–8 Hz) during the generation of convulsive activity in electrical kindling were studied in conscious guinea pigs. Overall electrical activity (EEG)was analyzed by wavelet transformation. Decreases in the coherence of theta oscillations recorded in both structures were(More)
Comparative studies of the GABAergic modulation of oscillations in neuron activity in the medial septal area were performed on living brain slices from healthy guinea pigs and animals with a model of chronic temporal epilepsy. Burst activity persisted only in pacemakers on administration of GABA in both groups of animals. The effectiveness of GABA on(More)
Inter-neuronal interactions within the medial septum/diagonal band complex (MSDB) are of great interest as this region is believed to be the hippocampal theta-rhythm pacemaker. However, the role of glutamatergic system in functioning of the septal cells is yet unclear. Here, we demonstrate for the first time the effects of glutamate in physiological(More)
Comparative studies of the activity of extracellularly recorded neurons in living slices of the medial septal area of healthy guinea pigs and animals with a model of chronic temporal epilepsy demonstrated differences between them in terms of the frequency and pattern of cell discharges. The brains of animals with experimental epilepsy showed a doubling of(More)
Septal slices from hibernating ground squirrels were initially (for two weeks) subjected to basal separation of the septal region and were then used for studies of the effects of neuropeptides extracted from the brains of hibernating animals (TSKYR, TSKY, and DY) and monoaminergic neurotransmitters (noradrenaline and serotonin) on neuronal responses evoked(More)
In earlier studies (Ivanov, Staneva-Stoycheva, 1984) we have found an inhibitory effect of metamyzole (Analgin-Pharmachim) on the contractile responses of electrically stimulated guinea-pig ileum and mouse vas deferens, which is antagonized by naloxone. In the present study an attempt is made to clarify whether these presynaptic effects of metamyzole are(More)
Male Wistar rats were trained for active (shuttle-box) and passive (step-down) conditioned avoidance through negative reinforcement. The memory tests carried out on the 24th hour and on the 7th day after the training revealed that the rats trained for active avoidance demonstrated a considerably higher number of avoidance in both tests, compared with the(More)
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